항암화학요법 및 방사선치료로 완전 관해된 진행성 식도암 1예
A Case of Complete Remission to Advanced Esophageal Cancer by a Concurrent Chemoradiation Therapy
강창무, 김종관, 김충배,
소속 상세정보
강창무 ( Kang Chang-Moo )
연세대학교 의과대학 외과학교실
김종관 ( Kim Jong-Kwan )
연세대학교 의과대학 외과학교실
김충배 ( Kim Choong-Bai )
연세대학교 의과대학 외과학교실
KMID : 0371320010610030329
Abstract
Esophageal cancer is still a virulent disease that leads to death. Surgery has been regarded as the treatment of choice in patients suffering this type of cancer and recent improvements in surgical techniques and perioperative management have
significantly increased the resection rate and reduced the operative mortality. Nevertheless, long-term survival rates remain poor. The poor prognosis reflects the fact that the disease is usually advanced at the time of diagnosis. Therefore, a
combination of chemotherapy and radiotherapy has recently been developed as a treatment for advanced esophageal cancer patients. Chemoradiation therapy is based on the concept of the biochemical modulation effects and radiosensitizing effects of
the
chemotherapeutic agents. How ever, the optimal choice of chemotherapeutic agents and their doses, as well as the chemotherapy and radiotherapy regimens
have not been precisely established. We report a case of concurrent chemoradiation protocol by which a complete response was achieved. 5-FU (1,800 mg/body/day) was continuously infused over 24 hours and cisplatin (45 mg/ body/day) was
administered
1
hour before radiotherapy for 3 days. This chemotherapy course was repeated once more after 4 weeks. The radiotherapy (180 cGy/day) was scheduled for 5 consecutive days, followed by a 2-day withdrawal, and a total dose of 5,940 cGy within 7 weeks.
Our
concurrent chemoradiation therapy is deemed rational, effective and safe because an endoscopically and pathologically complete response was achieved 1 year after chemoradiation therapy without any severe side effects. Therefore, we believe that
our
concurrent chemoradiation therapy can be recommended as a treatment for advanced esophageal cancer patients.
키워드
식도암; 완전관해; 병합요법; Esophageal cancer; Complete remission; Combination therapy;
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