유방암 골수 미세전이와 Plasminogen Activator Inhibitor-1의 관계
The Relationship between Plasminogen Activator Inhibitor-1 and Bone Marrow Micrometastases in Breast Cancer
윤정한, 제갈영종, 서순팔,
소속 상세정보
윤정한 ( Yoon Jung-Han )
전남대학교 의과대학 외과학교실
제갈영종 ( Jaegal Young-Jong )
전남대학교 의과대학 외과학교실
서순팔 ( Suh Soon-Pal )
전남대학교 의과대학 임상병리학교실
KMID : 0371320010610040373
Abstract
Purpose : Plasminogen Activator Inhibitor-1 (PAI-1) is the principal physiological urokinase-type plasminogen activator and is thought to regulate the overall invasive and metastatic behaviors of cancer cells. Although the occurrence of
bone
marrow micrometastases is an independent prognostic factor in breast cancer, its pathomechanism is not yet fully revealed until. We hypothesize that PAI-1 has a major role in the development of bone marrow micrometastases in breast cancer.
Accordingly,
we attempted to establish a correlation between PAI-1 activity in tumor tissues and bone marrow micrometastases in breast cancer. Additionally, we studied the relationship between PAI-1 level and selected clinicopathological characteristics such
as
tumor size, lymph node metastases, and steroid receptor positivity.
Methods : we used the RT-PCR targeting mRNA of cytokeratin 19 to detect bone marrow micrometastases and an ELISA kit to estimate PAI-1 activity in frozen tumor tissues.
Results : (1) The median PAI-1 level was 13.55 ng/㎖±16.38 in the cases with bone marrow metastases, and 6.02 ng/㎖±10.85 in the cases without bone marrow micrometastases. The difference was statistically significant (p-value=0.0165).
(2)
PAI-1
levels did not show any significant differences according to lymph node status, variation of tumor size or the expression status of the steroid receptors.
Conclusion : PAI-1 is considered to have a role to hematogenous metastases of breast cancer cells. However, fur-ther study is recommended to reveal its significance as an independent prognstic factor for breast cancer.
키워드
유방암; PAI-1; 골수 미세전이; Breast cancer; PAI-1; Bone marrow micrometastases;;
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