누드 마우스에 이종이식된 인형 위암 세포주에서 Meloxicam이 종양의 성장과 혈관 신생에 미치는 영향
The Effect of Meloxicam on Tumor Growth and Angiogenesis of Human Gatric Cancer Cell Line Xenograft in Nude Mice
이용진, 심우정, 차성재, 지경천, 박성준, 임현묵, 박성일, 이태진, 박언섭,
소속 상세정보
이용진 ( Lee Yong-Jin )
중앙대학교 의과대학 외과학교실
심우정 ( Sim Woo-Jung )
중앙대학교 의과대학 외과학교실
차성재 ( Cha Sung-Jae )
중앙대학교 의과대학 외과학교실
지경천 ( Chi Kyong-Chon )
중앙대학교 의과대학 외과학교실
박성준 ( Park Sung-Jun )
중앙대학교 의과대학 외과학교실
임현묵 ( Lim Hyun-Muk )
중앙대학교 의과대학 외과학교실
박성일 ( Park Sung-Il )
중앙대학교 의과대학 외과학교실
이태진 ( Lee Tae-Jin )
중앙대학교 의과대학 병리학교실
박언섭 ( Park Eon-Sub )
중앙대학교 의과대학 병리학교실
KMID : 0371320010610050465
Abstract
Purpose : In general, tumor growth is dependent on angiogenesis. COX, known as modulator of angiogenesis, consists of two at least isozymes constitutive COX-1 and stress-induced COX-2. The latter is known in case of gastric cancer to be
overexpressed in neoplastic tissue but not in adjacent normal tissue. To clarify the effect of COX-2 inhibitors on tumor growth and angiogenesis, we investigated the effects of Meloxicam (a selective COX-2 inhibitor) on gastric cancer xenograft
in
nude
mise that overexpress COX-2.
Methods : MKN45 gastric cancer cell lines that overexpress COX-2 were inoculated subcutaneously into athymic mice. The mean tumor volume, apoptotic index, proliferative index, microvessel count and angiogenic factors (VEGF and bFGF) were
measured
in the control group (12 cases) and the meloxicam treated group (23 cases).
Results : There was no significant difference of COX-2 expression between the control and meloxicam treated groups in mRNA level as measured by RT-PCR, nor in protein level by Western blotting. However, in the meloxicam treated group,
apoptosis
was increased to a statistically significant degree (P<0.01) while the proliferation index as measured by Ki-67, the mean tumor volume and angiogenesis were all significantly decreased, as compared with the control group (P<0.01).
Conclusion : The possible suppression of angiogenesis and tumor growth in gastric cancer xenograft by meloxicam suggests potentially. Novel and promising applications of COX-2 inhibitors in the adjuvant treatment of gastric cancer.
However,
further clinical study will be needed to determine its efficacy in such treatment modalities.
키워드
COX-2; Meloxicam; 위암; 혈관신생; COX-2; Meloxicam; Gastric cancer; Angiogenesis;
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