위암 환자의 암조직과 혈청 내 혈관내피 성장인자의 발현과 임상병리학적 소견 및 예후와의 상관관계
Expression of Vascular Endothelial Growth Factor in Cancer Tissues and Serum of Gastric Cancer Patients Correlation with Clinicopathologic Findings and Prognosis
류창학, 금주섭, 노성훈, 김충배, 이광형, 양우익,
소속 상세정보
류창학 ( Yoo Chang-Hak )
성균관대학교 의과대학 강북삼성병원 외과학교실
금주섭 ( Keum Joo-Seob )
성균관대학교 의과대학 강북삼성병원 해부병리과
노성훈 ( Noh Sung-Hoon )
연세대학교 의과대학 외과학교실
김충배 ( Kim Choong-Bai )
연세대학교 의과대학 외과학교실
이광형 ( Lee Kwang-Hyung )
연세대학교 의과대학 외과학교실
양우익 ( Yang Woo-Ick )
연세대학교 의과대학 병리학교실
KMID : 0371320020620010043
Abstract
Purpose : Vascular endothelial growth factor (VEGF) is known to be produced by various malignant tumors and thought to be involved in microvascular permeability and angiogenesis. However, the clinicopathologic significance of the
expression
of
VEGF in gastric cancer remains unclear.
Methods : To examine the relationship between VEGF expression in gastric cancer and clinicopathologic factors or patient survival, tumor VEGF expression was assessed by immunohistochemical study in 144 gastric cancer patients. In addition,
serum
VEGF (S-VEGF) level was measured by enzyme-linked immunosorbent assay in 116 patients and in 32 healthy controls.
Results : Positive staining for VEGF was observed in 68.8% (99 out of 144) of gastric cancers, and its expression was observed more frequently in patients with intestinal type and serosal invasion tumors. However, there was no significant
correlation between the patients’ survival and VEGF positivity. Significant differences in preoperative S-VEGF level were found between healthy controls and patients with gastric cancer (P=0.014), whereas there was no significant difference in
the
S-VEGF level between control and curative resection group. When S-VEGF levels were compared between groups categorized by different clinicopathologic variables, a significant correlation was found between a high S-VEGF level and a tumor size
greater
than 5 ㎝, serosal invasion, lymph node and distant metastasis. Moreover, postoperative S-VEGF levels were significantly elevated as compared to preoperative levels (P=0.000). When the median S-VEGF level was used as a cutoff level, the survival
rate of
patients with elevated S-VEGF levels was significantly lower than that of patients with low levels (P=0.001).
Conclusion : These results demonstrate that a high preoperative S-VEGF level is associated with tumor progression, metastasis and a poor outcome in patients with gastric cancer. Further studies are warranted to determine the clinical value
of
S-VEGF as an tumor marker and an indicator of tumor angiogenesis in gastric cancer.
키워드
위암; 혈관내피성장인자; 예후인자; Gastric cancer; Vascular endothelial growth factor; Prognostic factor;
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