COX-2 ¾ïÁ¦Á¦°¡ ´©µå¸¶¿ì½º¿¡ ÀÌ½ÄµÈ À§¾Ï¼¼Æ÷ÁÖ¿¡¼ Á¾¾çÀÇ ¼ºÀå°ú ÀüÀÌ¿¡¹ÌÄ¡´Â ¿µÇâ
The Effect of COX-2 Inhibitor on the Growth and Metastasis of Gastric CancerXenograft
¿ÀÁ¤½Ä, ½É¿ìÁ¤, Â÷¼ºÀç, Áö°æõ, ¹Ú¼ºÁØ, ÀÓÇö¹¬, ¹Ú¼ºÀÏ, ÀÌÅÂÁø, ¹Ú¾ð¼·,
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¿ÀÁ¤½Ä ( Oh Joung-Sik )
Áß¾Ó´ëÇб³ ÀÇ°ú´ëÇÐ ¿Ü°úÇб³½Ç
½É¿ìÁ¤ ( Sim Woo-Jung )
Áß¾Ó´ëÇб³ ÀÇ°ú´ëÇÐ ¿Ü°úÇб³½Ç
Â÷¼ºÀç ( Cha Sung-Jae )
Áß¾Ó´ëÇб³ ÀÇ°ú´ëÇÐ ¿Ü°úÇб³½Ç
Áö°æõ ( Chi Kyong-Chon )
Áß¾Ó´ëÇб³ ÀÇ°ú´ëÇÐ ¿Ü°úÇб³½Ç
¹Ú¼ºÁØ ( Park Sung-Jun )
Áß¾Ó´ëÇб³ ÀÇ°ú´ëÇÐ ¿Ü°úÇб³½Ç
ÀÓÇö¹¬ ( Lim Hyun-Muk )
Áß¾Ó´ëÇб³ ÀÇ°ú´ëÇÐ ¿Ü°úÇб³½Ç
¹Ú¼ºÀÏ ( Park Sung-Il )
Áß¾Ó´ëÇб³ ÀÇ°ú´ëÇÐ ¿Ü°úÇб³½Ç
ÀÌÅÂÁø ( Lee Tae-Jin )
Áß¾Ó´ëÇб³ ÀÇ°ú´ëÇÐ º´¸®Çб³½Ç
¹Ú¾ð¼· ( Park Eon-Sub )
Áß¾Ó´ëÇб³ ÀÇ°ú´ëÇÐ º´¸®Çб³½Ç
KMID : 0371320020620020095
Abstract
Purpose: Tumor invasion and metastasis are known to be extremely
important factors in the prognosis of cancer patients. Although recent
studies have demonstrated that cyclooxygenase-2 (COX-2) is overexpressed in
various cancers including gastric cancer, the mechanisms underlying the
contribution of COX-2 to tumorigenesis and tumor promotion remain unclear.
Methods: In order to determine the role of COX-2 in tumor growth and
metastasis, we investigated COX-2 expression, apoptosis and the expression
of E-cadherin, CD44v6, MMP-2 and TIMP-2 in gastric cancer xenografts treated
with meloxicam (a selective COX-2 inhibitor). Results: Cells from the
MKN45 gastric cancer cell line that overexpress COX-2 were inoculated
subcutaneously into athymic mice. Oral administration with meloxicam reduced
the tumor volume (P<0.01), induced apoptosis of cancer cells (P<0.01),
suppressed the proliferation rates (P<0.01), increased the expression of
E-cadhrin (P<0.05) and reduced the expression of MMP-2 and TIMP-2.
Conclusion: The above data showed that COX-2 inhibitors can inhibit
tumor growth and suppress metastatic potential by expression of adhesion
molecules and suppression of metalloproteinases, suggesting that this
inhibitor can be used as an additive anti-cancer drug in cases of stomach
cancer with radical resection, although further evaluation is required.
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COX-2; À§¾Ï; Á¾¾çÀÇ ¼ºÀå; ÀüÀÌ; COX-2; Gastric cancer; Tumor growth; Metastasis;
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