B형 간염 동반 원발성 간암 환자에서의 CYP2D6와 NAT2 다형 현상에 관한 연구
CYP2D6 and NAT2 Polymorphism in HBV Associated in Hepatocellular CarcinomaPatients in Korea
신동일, 이경근, 이광수, 조율희,
소속 상세정보
신동일 ( Shin Dong-Ill )
한양대학교 의과대학 외과학교실
이경근 ( Lee Kyeong-Geun )
한양대학교 의과대학 외과학교실
이광수 ( Lee Kwong-Soo )
한양대학교 의과대학 외과학교실
조율희 ( Cho Youl-Hee )
한양대학교 의과대학 유전학교실
KMID : 0371320020620020150
Abstract
Purpose: CYP2D6 and N-acetyltransferase (NAT2) are polymorphic
enzymes which are expressed in the hepatocyte in a genotype-determined
manner. They are known to be involved in the inactivation and activation of
various mutagens and carcinogens, respectively. The activities of the two
enzyme systems are associated with the genetic susceptibility of many human
cancers. Methods: This study was performed to determine the genotype
frequencies of the two enzyme systems in primary hepatocellular carcinoma
patients and healthy controls. One hundred healthy controls and 55 liver
cancer patients were analyzed by polymerase chain reaction-restriction
fragment length polymorphism (PCR-RFLP). Results: In the healthy
controls, the CYP2D6 wild type allele frequency was 0.985 and the CYP2D6*4
frequency was 0.015. No CYP2D6 poor-metabolizer was detected. No significant
differences were found in the hepatocellular carcinoma patients group. Among
the controls, the frequencies of F, S1, S2 and S3 alleles of the NAT2 system
were 0.725, 0.01, 0.14 and 0.125, respectively. The genotype frequencies
were found to be 0.91 for the rapid acetylator and 0.09 for the slow
acetylator. No significant differences were found in the hepatocellular
carcinoma group. Conclusion: The distribution of CYP2D6 and NAT2
polymorphism is very unique in the Korean population, as characterized by
the extremely low frequency of CYP2D6 poor-metabolizer and NAT2 slow
acetylator. CYP2D6 and NAT2 polymorphisms did not seem to play an important
role in the hepatic carcinogenesis in the Korean population.
키워드
원발성 간암; B형 간염; CYP2D6와 NAT2 다형현상; Hepatocellular carcinoma; Hepatitis B; CYP2D6 and NAT2 polymorphism;
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