C형 및 S형 단백 결핍에 의한 혈관 질환
Vascular Diseases Associated with Protein C and/or S Deficiencies
조용필, 이덕희, 정승문, 장혁재, 김지수, 한명식,
소속 상세정보
조용필 ( Cho Yong-Pil )
아산재단 강릉병원 외과학교실
이덕희 ( Lee Deok-Hee )
아산재단 강릉병원 진단방사선과학교실
정승문 ( Jung Seung-Mun )
아산재단 강릉병원 진단방사선과학교실
장혁재 ( Jang Hyuk-Jai )
아산재단 강릉병원 외과학교실
김지수 ( Kim Ji-Su )
아산재단 강릉병원 외과학교실
한명식 ( Han Myoung-Sik )
아산재단 강릉병원 외과학교실
KMID : 0371320020620020181
Abstract
Purpose: There are a number of conditions that can lead to a
hypercoagulable state, however, protein C and S deficiencies are frequently
described as causes of the hypercoagulable states. The aim of this study was
to evaluate the clinical features and prognosis of vascular diseases
associated with protein C and/or S deficiencies and to determine an adequate
treatment modality for such cases. Methods: We prospectively
evaluated 7 cases with vascular disease caused by protein C and/or S
deficiencies confirmed with serologic tests. Results: Four patients
showed venous thrombosis, 1 peripheral arterial insufficiency, 1 cerebral
venous thrombosis and peripheral arterial insufficiency, and 1 portal vein
thrombosis. Surgical intervention was required in 5 patients. Full
anticoagulation with heparin sodium followed by warfarin sodium was done in
all patients. Conclusion: Protein C and S deficiencies may influence
clinical management. Patients presenting with atypical vascular involvement
without evidence of other risk factors should be evaluated for a
hypercoagulable state. Once the diagnosis is made, patients should be
treated with full anticoagulation.
키워드
C형 및 S형 단백 결핍; 과응고 상태; 혈관질환; Protein C and S deficiencies; Hypercoagulable state; Vascular diseases;
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