결장 및 직장암에서 핵산 배수성 형태의 임상적 의의
Clinical Significance of DNA Ploidy Pattern in Patients with ColorectalCancer
정재성, 류성엽, 김형록, 김동의, 김영진,
소속 상세정보
정재성 ( Jeong Jae-Seong )
전남대학교 의과대학 외과학교실 위장관외과
류성엽 ( Ryu Sung-Yub )
전남대학교 의과대학 외과학교실 위장관외과
김형록 ( Kim Hyeong-Rok )
전남대학교 의과대학 외과학교실 위장관외과
김동의 ( Kim Dong-YI )
전남대학교 의과대학 외과학교실 위장관외과
김영진 ( Kim Young-Jin )
전남대학교 의과대학 외과학교실 위장관외과
KMID : 0371320020620030218
Abstract
Purpose: It is well known that the clinicopathologic stages of
colorectal cancer are correlated to the prognosis of patients and are used
to select the method of adjuvant treatment. Many studies suggest that the
DNA ploidy pattern is a supplementary prognostic marker. For that reason, we
studied the relationships between the DNA ploidy pattern and the incidence,
sex, age, tumor location, tumor size, histopathological classification,
stage, lymph node, liver, pertioneal metastases and prognosis in patients
with colorectal cancer. Methods: 373 patients with colorectal cancer
who had undergone surgical resection at the Hospital between January 1980
and January 2000 were studied. The DNA ploidy pattern was analyzed by
FACScan flow cytometry (Becton- Dickinson Immunocytometrical Systems,
Mountain View, CA). The relationships between DNA ploidy pattern and various
clinicopathologic characteristics were compared retrospectively.
Results: Cases of diploidy numbered 167 (44.8%) and aneuploidy 206
(55.2%). The mean size of the tumor mass was larger in the diploidy group.
DNA diplody was more frequent in ascending, transverse and descending colon
cancers. Aneuploidy was more frequent in sigmoid colon and rectal cancers.
In regards to histopathologic classification, mucinous & poorly
differentiated adenocarcinomas were inclined to diploidy and well
differentiated and moderately differentiated adenocarcinomas were inclined
to aneuploidy. Lymph node and liver metastases were more statistically
significant in the aneuploidy cases. The DNA ploidy pattern had no
significant correlation to age, sex, stage, peritoneal metastasis, or
prognosis. Conclusion: The DNA ploidy pattern is useful for
evaluating the biological behavior of tumors such as tumor growth, tumor
location, histopathological differentiation and lymph node metastasis,
although it is not useful for determining survival or prognosis.
키워드
대장암; 핵산 배수성; 예후; Colorectal cancer; DNA ploidy; Prognosis;
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