한국 유방암 환자의 체질량지수(BMI) 분포 및 부가 치료로서의 호르몬 치료에미치는 영향
Distribution and Prognostic Effect on Adjuvant Hormone Therapy of Body MassIndex (BMI) in Korean Breast Cancer Patients
민연기, 박중민, 김완배, 조성진, 김애리, 김남렬, 조민영, 정석인, 배정원, 구범환,
소속 상세정보
민연기 ( Min Youn-Ki )
고려대학교 의과대학 외과학교실
박중민 ( Park Joong-Min )
고려대학교 의과대학 외과학교실
김완배 ( Kim Wan-Bae )
고려대학교 의과대학 외과학교실
조성진 ( Cho Seong-Jin )
고려대학교 의과대학 병리학교실
김애리 ( Kim Ae-Ree )
고려대학교 의과대학 병리학교실
김남렬 ( Kim Nam-Ryeol )
고려대학교 의과대학 외과학교실
조민영 ( Cho Min-Young )
고려대학교 의과대학 외과학교실
정석인 ( Jung Suk-In )
고려대학교 의과대학 외과학교실
배정원 ( Bae Jung-Won )
고려대학교 의과대학 외과학교실
구범환 ( Koo Bum-Hwan )
고려대학교 의과대학 외과학교실
KMID : 0371320020620040275
Abstract
Purpose: Obesity has been shown to have important effects related to
breast cancer. But there have been few data available on the distribution of
body mass index (BMI) among Korean breast cancer patients and on the
effects of this distribution on patient prognosis. Therefore we investigated
the BMI distribution of Korean breast cancer patient’s and its relationship
with other tumor markers, in order to elucidate the relationship between BMI
and patient prognosis. Methods: We measured the BMI of 266 Korean
adult women with breast carcinoma.and divided the subjects into the
following subgroups according to BMI; low body weight (BMI<20), normal body
weight (BMI; 20∼25) and over weight (BMI≥25). We compared this
distribution with that of the general Korean women’s population. and
investigated the correlation with other prognostic factors and tumor
markers. The 5 year overall and disease free survival rates were evaluated
for both the total breast cancer patients and the adjuvant hormone treated
breast cancer patients, according to BMI subgroup, using the Kaplan-Meier
method. Results: Mean BMI for the breast patients was 23.4±3.1, and
did not differ from that of the general Korean adult women’s population
(’1994 National Nutrition Survey Report). BMI increased with increasing age
and was highest in the 60∼69 yr age group. BMI was correlated with tumor
size and stage. The survival rates were low in the high BMI group among both
total and adjuvant hormone treated breast cancer patients, but in neither
was any statistical difference found between BMI subgroups.
Conclusion: Korean breast cancer patients are not obese as the
general population and their BMI increases with increasing age and
menopausal status. There was a tendency for higher BMI to be associated with
poorer prognosis, although not to a statistically significant degree.
키워드
유방암; 체질량지수; 예후인자; Breast cancer; Body mass index (BMI); Prognostic factor;
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