결직장암에서 CD44s, CD44v5, CD44v6, p27kip1의 발현 양상
The Expression of CD44s, CD44v5, CD44v6, p27kip1 in ColorectalCarcinoma
정인철, 김기홍, 박용진, 송병주, 이명수, 김철남, 장석효, 원종만, 김지일,
소속 상세정보
정인철 ( Jung In-Chul )
인제대학교 의과대학 외과학교실
김기홍 ( Kim Ki-Hong )
인제대학교 의과대학 외과학교실
박용진 ( Park Young-Jin )
인제대학교 의과대학 외과학교실
송병주 ( Song Byung-Joo )
인제대학교 의과대학 외과학교실
이명수 ( Lee Myung-Soo )
인제대학교 의과대학 외과학교실
김철남 ( Kim Chul-Nam )
인제대학교 의과대학 외과학교실
장석효 ( Chang Seok-Hyo )
인제대학교 의과대학 외과학교실
원종만 ( Won Jong-Man )
가톨릭대학교 의과대학 외과학교실
김지일 ( Kim Ji-Il )
인제대학교 의과대학 외과학교실
KMID : 0371320020620040319
Abstract
Purpose: In treating colorectal carcinoma, metastasis and recurrence
are the most important problems encountering after a curative resection of
the tumor. Therefore, understanding the mechanism of the disease progression
and being able to predict the likelihood of recurrence is very important.
Methods: In this study, 56 colorectal carcinoma cases were reviewed.
Immunohistochemical staining on CD44s, CD44v5, CD44v6, and
p27kip1 were performed to determine the expression level of the
protein, the patient’s clinical findings and the pathophysiology.
Results: 1) CD44v5 showed a positive response in 47 (83.9%) out of 56
cases. By analyzing the Astler-Coller classification and the invasion of the
lymphatic system, the value expressed was significantly high. 2)
p27kip1 showed a positive response in 35 (62.5%) out of 56 cases.
As the disease progressed, there was a significant decrease according to
analysis of Astler-Coller classification, and the invasion of the lymph node
and lymphatics. The relationship showed an inverse correlation as the
disease progressed. 3) For the CD44s and CD44v6, analysis by the
Astler-Coller classification, the histological pattern, lymph node
metastasis, invasion of the lymphatic system and the depth of the invasion,
were not significantly different. Conclusion: CD44v5 and
p27kip1 have a relationship with tumor progression, and is a
valuable marker for prognosis. In particular, CD44v5 appeared to be involved
in tumor progression where the tumor cells invaded the lymphatic system.
키워드
결직장암; CD44; p27kip1; Colorectal carcinoma; CD44; p27kip1;
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