유방암 환자에서 c-erbB-2, p53, bcl-2, 그리고 c-myc의 발현유무와 임상적 의의
Clinical Correlation of c-erbB-2, p53, bcl-2, and c-myc Expression in Patients with Breast Cancer
최남규, 김성용, 김태윤, 채만규, 백무준, 임철완, 박내경, 이문수, 김현철, 김창호, 이민혁, 송옥평, 김은석, 황규윤, 양승하, 조무식,
소속 상세정보
최남규 ( Choi Nam-Kyu )
순천향대학교 천안병원 외과학교실
김성용 ( Kim Sung-Yong )
순천향대학교 천안병원 외과학교실
김태윤 ( Kim Tae-Yoon )
순천향대학교 의과대학 천안병원 외과학교실
채만규 ( Chae Man-Kyu )
순천향대학교 의과대학 천안병원 외과학교실
백무준 ( Baek Moo-Jun )
순천향대학교 의과대학 천안병원 외과학교실
임철완 ( Lim Cheol-Wan )
순천향대학교 의과대학 천안병원 외과학교실
박내경 ( Park Nae-Kyung )
순천향대학교 의과대학 천안병원 외과학교실
이문수 ( Lee Moon-Soo )
순천향대학교 의과대학 천안병원 외과학교실
김현철 ( Kim Hyung-Chul )
순천향대학교 의과대학 천안병원 외과학교실
김창호 ( Kim Chang-Ho )
순천향대학교 의과대학 천안병원 외과학교실
이민혁 ( Lee Min-Hyuk )
순천향대학교 의과대학 천안병원 외과학교실
송옥평 ( Song Ok-Pyung )
순천향대학교 의과대학 천안병원 외과학교실
김은석 ( Kim Eun-Seog )
순천향대학교 의과대학 방사선종양학교실
황규윤 ( Hwang Kyu-Yoon )
순천향대학교 천안병원 예방의학교실
양승하 ( Yang Seung-Ha )
순천향대학교 의과대학 천안병원 병리학교실
조무식 ( Cho Moo-Sik )
순천향대학교 의과대학 천안병원 외과학교실
KMID : 0371320020620050371
Abstract
Purpose: Breast cancer is a common malignant tumor in Korean women. Various oncogenes have been demonstrated in malignant tumor cells. There were many reports on the relationship between the prognosis and the tumor markers, particularly c-erbB-2, p53, bcl-2, and c-myc. However, this relationship is controversial. The aim of this study was to perform immunohistochemical staining for the c-erbB-2, p53, bcl-2, and c-myc antigenic protein in breast cancer patients, to evaluate the expression rate of each antigen, and to compare the correlations with the patients’ prognosis.
Methods: The medical records of 80 patients who were diagnosed with breast cancer and who were treated with a mastectomy between January 1993 and December 1996 at Soonchunhyang University Chunan Hospital were selected according to the condition of the paraffin block fixation. The prognostic factors were investigated. The immunohistochemical expression of c-erbB-2, p53, bcl-2, and c-myc was examined and compared with the survival rate using a Kaplan-Meier estimate and a log rank test.
Results: Eighty patients (79 females, 1 male) were included in this study, with a mean (SD) age of 48.2 (10.6) years and follow-up duration of 59.9 (24.9) months. The overall mortality was 41.3 (33/80)% and the mean (SD) survival time was 77 (4) months. The overall 5-year survival rate was 63.3%. Among the study variables, the tumor stage was a significant predictor of survival showing a significantly low survival rate in tumor stage Ⅲ. The tumor size and lymph node metastasis were significantly associated with the survival rate in patients with breast cancer.
Conclusions: c-erbB-2, p53, bcl-2, and c-myc might be useful prognostic factors, even though a statistical significance was not achieved.
키워드
유방암; 예후인자
c-erbB-2; p53; bcl-2; c-myc; Breast cancer; Prognostic factor; c-erbB-2; p53; bcl-2; c-myc
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