유방암 환자에서 방사선 동위원소 및 Isosulfan Blue Dye를 이용한 감시림프절 생검
Sentinel Lymph Node Biopsy Using Technetium- 99m Antimony Sulfide Colloid and Isosulfan Blue Dye in Breast Cancer Patients
박종민, 진성호, 김명욱, 임현이, 박찬희, 정경일, 박희붕,
소속 상세정보
박종민 ( Park Jong-Min )
아주대학교 의과대학 외과학교실
진성호 ( Jin Sung-Ho )
아주대학교 의과대학 외과학교실
김명욱 ( Kim Myung-Wook )
아주대학교 의과대학 외과학교실
임현이 ( Yim Hyun-Ee )
아주대학교 의과대학 병리학교실
박찬희 ( Park Chan-Hee )
아주대학교 의과대학 핵의학교실
정경일 ( Chung Kyung-Il )
아주대학교 의과대학 진단방사선과학교실
박희붕 ( Park Hee-Boong )
아주대학교 의과대학 외과학교실
KMID : 0371320020620050389
Abstract
Purpose: Sentinel lymph node (SLN) biopsy is a useful method for assessing axillary nodal status and selecting axillary dissection in breast cancer patients. The goals of our study were to evaluate the detection rate of SLN and determine
the
accuracy of SLN biopsy in predicting axillary nodal status using technetium radiolabeled sulfur colloid and isosulfan blue dye.
Methods: Between January and August 2001, 55 breast cancer patients with clinically node negative results underwent SLN biopsy from the Department of Surgery at Ajou University Hospital. Both technetium radiolabeled sulfur colloid and
isosulfan
blue dye were used to guide SLN biopsy. SLN biopsy was always followed by a complete axillary dissection. The histopathology of SLNs determined from frozen sectioning and serial sectioning was compared with that of the nonsentinel nodes evaluated
with
routine Hematoxylin and Eosin stain.
Results: The overall SLN detection rate was 85.4% (47 of 55 patients). The staging accuracy of SLN biopsy was 97.9% (46 of 47 patients), the sensitivity 92.3% (12/13), the false negative rate 7.7% (1/13), and the negative predictive value
97.1%
(34 of 35).
Conclusions: Our study was a pilot study for SLN biopsy. SLN biopsy was more effective when a combination of technetium radiolabeled sulfur colloid and isosulfan blue dye were used. The results of our study support the hypothesis that SLN
biopsy
is an accurate predictor of axillary nodal status. SLN biopsy may be applicable to early breast cancer patients and thereby allow the omission of routine axillary dissection in selected cases.
키워드
감시림프절; 유방암; Isosulfan blue dye; 방사선동위원소; Sentinel lymph node; Breast cancer; Isosulfan blue dye; Radioiosotope;
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