유방의 침윤성 관암종에서 Insulin-like Growth Factor I Receptor의 발현과 병리학적 예후인자의 상관관계
Correlation between Expression of Insulin-like Growth Factor-I Receptor and Clinicopathologic Prognostic Factors in Invasive Ductal Carcinoma of the Breast
오소영, 강명재, 문우성, 최호열,
소속 상세정보
오소영 ( Oh So-Yeong )
남원의료원
강명재 ( Kang Myoung-Jae )
전북대학교 의과대학 병리학교실
문우성 ( Moon Woo-Sung )
전북대학교 의과대학 병리학교실
최호열 ( Choi Ho-Yeul )
전북대학교 의과대학 병리학교실
KMID : 0371320020620050396
Abstract
Purpose: The insulin-like growth factor-I receptor (IGF-IR) is a member of the transmembrane tyrosine kinase family that regulates various biological processes. These processes include maintaining optimal cell growth, establishing and
maintaining
the transformed phenotype, tumorigenesis for several types of cells, and antiapoptosis. This study investigated the immunohistochemical expression of IGF-IR in relation with the expression of the estrogen receptor (ER), the progesteron receptor
(PR),
proliferative activity (Ki-67) as well as with the other conventional clinicopathlogical parameters in breast cancer.
Methods: This study was performed on paraffin sections from 64 invasive ductal breast carcinoma specimens by immunohistochemistry using rabbit polyclonal antibodies to the IGF-I receptor.
Results: IGF-IR expression was detected in 56 (87.5%) cases. The immunohistochemical stains for the IGF-IR were scored according to a semi quantitative scoring system. IGF-IR staining was positively correlated with the ER status, but not
significantly with the PR, lymph node status, tumor size, histological grade, and proliferative activity. The Ki-67 labeling index showed a significant correlation with the tumor grade and ER status.
Conclusions: The IGF-IR may play a role in estrogen-mediated growth and the pathogenesis of breast cancer.
키워드
유방암; IGF-I 수용체; 에스트로겐 수용체; 프로게스테론 수용체; Ki-67; Breast cancer; IGF-I receptor; Estrogen receptor; Progesteron receptor; Ki-67;
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