유방의 양성종양과 악성종양에서 Phospholipase C-γ1의 발현양상
The Pattern of Expression of Phospholipase C-γ1 in Benign and Malignant Tumors of the Breast
김희정, 정기욱, 김성원, 문병인, 안수정, 노동영, 유근영, 최국진,
소속 상세정보
김희정 ( Kim Hee-Joung )
서울대학교 의과대학 외과학교실
정기욱 ( Chung Ki-Wook )
서울대학교 의과대학 외과학교실
김성원 ( Kim Sung-Won )
서울대학교 의과대학 외과학교실
문병인 ( Moon Byung-In )
이화여자대학교 의과대학 외과학교실
안수정 ( Ahn Soo-Jung )
서울대학교 의과대학 암연구소
노동영 ( Roh Dong-Young )
서울대학교 의과대학 암연구소
유근영 ( Yoo Keun-Young )
서울대학교 의과대학 예방의학교실
최국진 ( Choi Kook-Jin )
서울대학교 의과대학 외과학교실
KMID : 0371320020620060463
Abstract
Purpose: The activation of phospholipase C (PLC) is one of the early events in various growth processes, including malignant transformation. Among PLC-isozymes, PLC-γ1 is activated through direct interaction with growth factor receptor
tyrosine
kinase. In this study, we evaluated the patterns of PLC-γ1 expression in benign and malignant tumors of the breast and compared the patterns with their normal counterpart.
Methods: Using immunoblot assay, we evaluated the patterns of expression in PLC-γ1 in 20 breast cancer tissues, 13 fibroadenoma tissues, and normal tissues. The level of expression was analyzed by densitometry.
Results: All of 20 breast cancer tissues and 13 fibroadenoma tissues showed overexpression of PLC-γ1 when compared with their normal counterparts. The level of the PLC-γ1 expression was 3.9-fold and 17.3-fold higher in fibroadenomas and
breastcancers, respectively, than in normal tissues.
Conclusions: The result suggested that the level of PLC-γ1 expression increases as the normal tissue undergoes progression to fibroadenoma, and finally to carcinoma. The pattern of expression of PLC-γ1 in breast tissue implies that the
PLC-γ1-mediated signal transduction may play a significant role in the progression of breast cancer from normal tissue.
키워드
Phospholipase C-γ1; 섬유선종; 유방암; PLC-γ1; Fibroadenoma; Breast cancer;
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