유방암에서 Nitric Oxide Synthase의 발현
Nitric Oxide Synthase (NOS) Expression in Breast Cancer
이해경, 조백현, 허민희, 강성수, 이지현, 이성공, 김혜정, 김의정, 문병산, 김세중, 한혜승, 주영채, 신석환,
소속 상세정보
이해경 ( Lee Hae-Kyung )
성균관대학교 의과대학 삼성제일병원 일반외과
조백현 ( Cho Back-Hyun )
성균관대학교 의과대학 삼성제일병원 외과
허민희 ( Hur Min-Hee )
성균관대학교 의과대학 삼성제일병원 일반외과
강성수 ( Kang Sung-Soo )
성균관대학교 의과대학 삼성제일병원 외과
이지현 ( Lee Jee-Hyun )
성균관대학교 의과대학 삼성제일병원 외과
이성공 ( Lee Sung-Kong )
성균관대학교 의과대학 삼성제일병원 외과
김혜정 ( Kim Hae-Jeung )
성균관대학교 의과대학 삼성제일병원 병리과
김의정 ( Kim Yee-Jeong )
성균관대학교 의과대학 삼성제일병원 병리과
문병산 ( Moon Byoung-San )
인하대학교 의과대학 외과학교실
김세중 ( Kim Sei-Joong )
인하대학교 의과대학 외과학교실
한혜승 ( Han Hye-Seung )
인하대학교 의과대학 병리학교실
주영채 ( Chu Young-Chae )
인하대학교 의과대학 병리학교실
신석환 ( Shin Suk-Hwan )
인하대학교 의과대학 외과학교실
KMID : 0371320020630020105
Abstract
Purpose: NO, a diatomic free radical, plays a diverse physiological and pathophysiological roles in the vascular, neuronal and immune systems. It is produced by nitric oxide synthase (NOS) which consists of three different isoforms. In this
study
we investigated NOS expression in 84 human breast carcinomas and its associations to other clinicopathological factors.
Methods: The immunohistochemical staining for NOS expression in 84 human breast carcinomas were performed and their medical records were reviewed retrospectively.
Results: iNOS expression in tumor cells was observed in 48.2% and eNOS expression was detected in 51.9%. iNOS expression in tumor cells has positive correlation with eNOS expression in tumor and is associated with iNOS expression in stroma
and
endothelial cells. Although iNOS expression in tumor cells has negative correlation with tumor size (P=0.047) and lymph node metastasis (P=0.002), it has no effects on 5 year overall and disease free survivals. iNOS expression in stroma also has
negative correlation with tumor size (P=0.016) and nuclear grade (P=0.025). No significant correlation between eNOS expression and clinicopathological factors was observed but eNOS expression in tumor cells contributed to worse 5 year overall
survivals
(92.1% vs 77.0%) in marginal significance (P=0.053).
Conclusion: These data suggest that iNOS expression in tumor may have an inhibitory effect in tumor growth and lymph node metastasis. These results may be further investigated.
키워드
Nitric oxide synthase (NOS); 유방암; 림프절 전이; Nitric oxide synthase (NOS); Breast Cancer; Lymph Node Metastasis;
원문 및 링크아웃 정보
등재저널 정보