담낭 선종과 암종에서 β-catenin의 발현 양상
The Pattern of β-Catenin Expression in Adenomas and Carcinomas of the Gallbladder
문종호, 최창수, 양영일, 백계형, 최영길,
소속 상세정보
문종호 ( Moon Jong-Ho )
인제대학교 부산백병원 외과학교실
최창수 ( Choi Chang-Soo )
인제대학교 부산백병원 외과학교실
양영일 ( Yang Young-Il )
인제대학교 의과대학 병리학교실
백계형 ( Paik Kye-Hyung )
인제대학교 백인제기념임상의학연구소
최영길 ( Choi Young-Kil )
인제대학교 부산백병원 외과학교실
KMID : 0371320020630020138
Abstract
Purpose: β-catenin is a key regulator of the cadherin- mediated cell adhesion system and also plays a role as a transcription regulating factor. Nuclear expression and mutation of β-catenin have been identified in some benign and
malignant
tumors, and over expression of β-catenin indicates an oncogenic potential. This study was designed to clarify the role of β-catenin in the histogenesis of gallbladder carcinoma.
Methods: In benign hyperplastic lesions, adenomas, and carcinomas of the gallbladder, intracellular expression of β-catenin was investigated by immunohistochemical stainings. Cyclin D1 and Ki-67 were also examined.
Results: All of the hyperplastic lesions showed membranous expression of β-catenin. Adenomas and polypoid carcinomas showed significantly higher incidence of cytoplasmic and nuclear expression of β-catenin than hyperplastic lesions and
infiltrative carcinomas (P＜0.01). Loss of β-catenin expression was frequently noticed in infiltrative and poorly differentiated carcinomas. Nuclear expression of β-catenin in carcinomas had unique pathologic characteristics, including polypoid
growing, well differentiated tubular type, and early stage. Cytoplasmic and nuclear expression of β-catenin showed good correlations with cyclin-D1 expression (P＜0.05). The Ki-67 index was significantly higher in infiltrative carcinomas than in
adenomas or polypoid carcinomas (P＜0.05).
Conclusion: Our results suggest that β-catenin as a molecular marker may play a role in the carcinogenesis of the adenoma-carcinoma sequence of polypoid carcinomas. Infiltrative carcinomas, however, may have different mechanisms.
키워드
β-catenin; 선종; 암종; 담낭; β-catenin; Adenoma; Carcinoma; Gallbladder;
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