이식신 생검에서 비만 세포(Mast Cells)의 임상적 의의
Mast Cells in Renal Allografts
이재춘, 이삼열, 박성길, 김승일, 이영철, 김주섭, 주선형, 오국환, 채동완, 남은숙, 박철재,
소속 상세정보
이재춘 ( Lee Jae-Chun )
한림대학교 의과대학 외과학교실
이삼열 ( Lee Sam-Uel )
한림대학교 의과대학 외과학교실
박성길 ( Park Sung-Gil )
한림대학교 의과대학 외과학교실
김승일 ( Kim Seung-Il )
한림대학교 의과대학 외과학교실
이영철 ( Lee Young-Cheol )
한림대학교 의과대학 외과학교실
김주섭 ( Kim Joo-Seop )
한림대학교 의과대학 외과학교실
주선형 ( Joo Sun-Hyung )
한림대학교 의과대학 외과학교실
오국환 ( Oh Kook-Hwan )
한림대학교 의과대학 내과학교실
채동완 ( Chae Dong-Wan )
한림대학교 의과대학 내과학교실
남은숙 ( Nam Eun-Suk )
한림대학교 의과대학 병리학교실
박철재 ( Park Chul-Jae )
한림대학교 의과대학 외과학교실
KMID : 0371320020630030201
Abstract
Purpose: Chronic rejection is the enemy in the battle for long term survival after renal allografts. Interstitial fibrosis is known to be the important finding in renal allografts with chronic rejection. Mast cells secrete a large number
of
fibrogenic factors and have been involved in chronic inflammation and tissue fibrosis. In this study the authors evaluated the relationship between mast cells and fibrosis in renal allografts with chronic rejection.
Methods: The authors evaluated 42 biopsied specimens of renal allografts. Immunohistochemistry using anti-mast cell tryptase (Dako, 1：200) and an LSAB kit (Dako) was applied to detect mast cells. The mean number of mast cells (MNM) per 10
high
power fields was counted.
Results: MNM of implantation biopsies was 0.640±0.537, of acute rejection -1.969±1.216, of chronic rejection -6.0±3.133 (P＜0.01), of acute tubular necrosis -1.360±0.899, and of acute cyclosporine nephrotoxicity -1.000±0.600. MNM
according
to donor source was 3.267±3.479 vs. 2.376±1.900 (living donors vs. cadaveric donors). MNM was significantly correlated with donor sex (male：female ratio of = 2.319±1.739：4.014±4.286, P＜0.01), and cholesterol (hypercholesterolemia vs.
non-hypercholesterolemia, 4.125±5.497 vs. 2.60±1.916, P＜0.01). However, MNM according to blood pressure was not statistically significant (hypertension：non-hypertension ratio of=3.189±3.05：1.200±1.226, P＞0.05).
Conclusion: Our data show that the number of mast cells in renal allograft was significantly associated with chronic rejection, donor sex and hypercholesterolemia.
키워드
신이식; 만성 거부반응; 비만 세포; Renal transplantation; Chronic rejection; Mast cells;
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