간담췌 질환에서 CA 19-9의 양성률 고찰
Clinical Analysis of CA19-9 Positive Rate of Hepatobiliary Pancreas Disease
채윤석, 김경식, 이효상, 이우정, 김병로,
소속 상세정보
채윤석 ( Chae Yoon-Seok )
관동대학교 의과대학 외과학교실
김경식 ( Kim Kyung-Sik )
연세대학교 의과대학 외과학교실
이효상 ( Lee Hyo-Sang )
연세대학교 의과대학 외과학교실
이우정 ( Lee Woo-Jung )
연세대학교 의과대학 외과학교실
김병로 ( Kim Byong-Ro )
연세대학교 의과대학 외과학교실
KMID : 0371320020630030227
Abstract
Purpose: CA19-9 is the most widely used pancreatic-tumor marker, and has become the standard against which other makers. However, the CA19-9 level is increased in conditions such as gallbladder cancer, cholangiocarcinoma, hepatocellular
carcinoma, gallbladder polyp, acute cholangitis, and chronic pancreatitis. Therefore, this study aimed to determine the CA19-9 positive rate of the above diseases in Korea.
Methods: A positive result was considered if the upper limit of normal was 37∼40 μ/㎖. The CA19-9 level was measured in 53 patients with pancreatic cancer, 72 with cholangiocarcinoma, 41 with common bile duct cancer, 27 with gallbladder
cancer,
35 with hepatocellular cancer, 70 with acute pancreatitis, 93 with chronic pancreatitis, and 30 with a gallbladder polyp from September 1998 to December 2000 in the Severance hospital.
Results: When the cut-off value was ＞40 μ/㎖, a positive result was found in 79.2% (42/53) of pancreatic cancer patients, 58.3% (42/72) of cholangiocarcinoma patients, 37% (10/27) of gallbladder cancer patients, 31.7% (13/41) of common
bile
duct cancer patients, 19.7% (14/70) of acute pancreatitis patients, 14.2% (5/35) of hepatocellular cancer patients, 16% (5/93) of chronic pancreatitis patients, and the 3.3% (1/30) of patients with a gallbladder polyp.
Conclusion: The highest positive rate was 79.2% in the pancreatic cancer patients. We confirmed that the Lewis phenotype distribution indieates that pancreatic cancer, cholangiocarcinoma, and chronic pancreatitis show high frequency in
Le(a-b-)
group when they were statistically compared with a healthy control group, but that acute pancreatitis showed a stastically higher frequency in the Le(a+b-) group than chronic pancreatitis.
키워드
CA19-9; 췌장암; CA19-9; Pancreatic cancer;
원문 및 링크아웃 정보
등재저널 정보