유방암의 Cyclin E 발현과 임상소견의 상관성 분석
The Correlations between the Expression of Cyclin E and Clinical Features of the Primary Breast Cancer
박재우, 양근호, 배병노, 김기환, 김홍주, 김영덕, 김홍용, 박경미, 한세환,
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박재우 ( Park Jae-Woo )
인제대학교 의과대학 상계백병원 외과학교실
양근호 ( Yang Keun-Ho )
인제대학교 의과대학 상계백병원 외과학교실
배병노 ( Bae Byung-Noe )
인제대학교 의과대학 상계백병원 외과학교실
김기환 ( Kim Ki-Whan )
인제대학교 의과대학 상계백병원 외과학교실
김홍주 ( Kim Hong-Joo )
인제대학교 의과대학 상계백병원 외과학교실
김영덕 ( Kim Young-Duck )
인제대학교 의과대학 상계백병원 외과학교실
김홍용 ( Kim Hong-Yong )
인제대학교 의과대학 상계백병원 외과학교실
박경미 ( Park Kyeong-Mee )
인제대학교 의과대학 상계백병원 병리학교실
한세환 ( Han Se-Hwan )
인제대학교 의과대학 상계백병원 외과학교실
KMID : 0371320020630050372
Abstract
Purpose: Cyclin E is a key regulatory protein in the G1-S transition during the cell cycle. The correlations between cyclin E protein and the clinical features of breast cancer were investigated in order to evaluate its clinical utility
in
invasive breast cancer.
Methods: An immunohistochemical assay for cyclin E was performed in 101 consecutive invasive breast cancers. The correlation between cyclin E expression and the clinicobiological parameters including patient survival was analyzed.
Results: Cyclin E expression was observed in 50 patients (49.5%). The scoring of the cyclin E expression level was divided into low (＜25%) and high (≥25%). In high nuclear grade tumors, cyclin E overexpression was much higher than that in
low
nuclear grade tumors (P=0.049). In the younger age group (＜50 yrs), cyclin E expression was significantly higher than the older age group (P=0.016). No significant correlation was observed between cyclin E and the tumor size, lymph node status,
hormonal receptor status, histological grade, mitotic index and Ki67. In multivariate analysis, only the lymph node status was significantly associated with the patients’ outcome (P=0.002).
Conclusion: Cyclin E overexpression did not have prognostic impact on the patients’ survival rate in invasive breast cancer. In high nuclear grade tumors, the cyclin E expression level was much higher. The definite value of cyclin E as a
clinicobiologic marker should be further investigated by prospective studies with other cell regulatory proteins.
키워드
세포증식; 예후; 유방암; 핵분화도; Cyclin E; Breast cancer; Cell proliferation; Cyclin E; Nuclear grade; Prognosis;
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