갑상선 종양에서 Fas 및 Fas Ligand 발현의 임상적 의의
The Clinical Significance of Fas and Fas Ligand Expression in Thyroid Neoplasms
김태형, 민연기, 조성진, 손길수, 배정원, 김종석, 구범환,
소속 상세정보
김태형 ( Kim Tae-Hyoung )
고려대학교 의과대학 외과학교실
민연기 ( Min Youn-Ki )
고려대학교 의과대학 외과학교실
조성진 ( Cho Seong-Jin )
고려대학교 의과대학 병리학교실
손길수 ( Son Gil-Soo )
고려대학교 의과대학 외과학교실
배정원 ( Bae Jung-Won )
고려대학교 의과대학 외과학교실
김종석 ( Kim Chong-Suk )
고려대학교 의과대학 외과학교실
구범환 ( Koo Bum-Hwan )
고려대학교 의과대학 외과학교실
KMID : 0371320020630060462
Abstract
PURPOSE: Recent studies indicate that Fas and Fas Ligand (Fas-L) are implicated in autoimmune endocrine diseases and tumors of the thyroid. In this study we tried to elucidate the expression stati of Fas and Fas-L in some kinds of thyroid neoplasms, and
their relationships with 4 prognostic factors in papillary thyroid cancer (i.e., size, lymph node metastasis, capsule invasion, age). METHODS: 66 cases of thyroid neoplasm including 45 cases of papillary cancer (PTC), 3 of a follicular cancer (FTC), 1
of a poorly differentiated cancer (PDC), 1 of a undifferentiated cancer (UC), 7 of follicular adenoma (FA), and 9 of nodular hyperplasia (NH) were examined, and estimated as negative, weak positive and strong positive about the Fas and Fas-L expression
by the immunohistochemical staining intensities. We then collected and compared the differrences between benign and malignant tumors. The expressions of Fas and Fas-L in papillary thyroid cancers were evaluated relating to the differences in the
prognostic factors (i.e., the size, lymph node status, capsule invasion, and age of the patients). RESULTS: Malignant thyroid tumors revealed stronger staining intensity than benign neoplasms. In papillary thyroid cancers, Fas-L staining intensities
were significantly stronger in the cases with perithyroidal lymph node metastasis, or in those of 45 years old or over than in those with no lymph node metastasis, or younger than 45 years. CONCLUSION: Both Fas and Fas-L are implicated in thyroid
tumorigenesis and revealed stronger staining intensities in malignant than benign tumors, and the Fas-L staining intensities may have some prognostic implications at least in papillary thyroid cancers.
키워드
갑상선 종양; Fas; Fas ligand (Fas-L); Thyroid neoplasms; Fas; Fas ligand (Fas-L);
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