결직장암에서 COX-2발현의 임상적 의의
The Clinical Significance of Cyclooxygenase 2 Expression in Colorectal Cancer
장현록, 배병노, 양근호, 한세환, 김홍주, 김홍용, 김영덕, 김기환, 김정연,
소속 상세정보
장현록 ( Jang Hyun-Rok )
인제대학교 상계백병원 외과학교실
배병노 ( Bae Byung-Noe )
인제대학교 의과대학 상계백병원 외과학교실
양근호 ( Yang Keun-Ho )
인제대학교 의과대학 상계백병원 외과학교실
한세환 ( Han Se-Hwan )
인제대학교 의과대학 상계백병원 외과학교실
김홍주 ( Kim Hong-Ju )
인제대학교 의과대학 상계백병원 외과학교실
김홍용 ( Kim Hong-Yong )
인제대학교 의과대학 상계백병원 외과학교실
김영덕 ( Kim Young-Duck )
인제대학교 의과대학 상계백병원 외과학교실
김기환 ( Kim Ki-Whan )
인제대학교 의과대학 상계백병원 외과학교실
김정연 ( Kim Jung-Yoen )
인제대학교 의과대학 상계백병원 병리학교실
KMID : 0371320030640010039
Abstract
Purpose: Epidemiologic studies have indicated that the use of nonsteroidal anti-inflammatory drugs, which inhibit cyclooxygenase activity, reduce the risk of colorectal cancer. In addition, several studies have demonstrated the increased expression of cyclooxygenase-2 (COX-2) in human colorectal cancer tissues. However, the role of COX-2 in colorectal cancer has not been fully established. The aim of this study was to clarify the clinicopathologic significance of COX-2 expression in human colorectal cancer.
Methods: We performed immunohistochemical straining for COX-2 expression in 124 human colorectal cancer specimens. COX-2 expression was then compared with clinicopathologic factors and survival outcomes.
Results: COX-2 was expressed in the cytoplasm of the cancer cells. COX-2 expression was noted in 86.3% of the cancer patients and significantly correlated with the histologic type. The depth of invasion ,tumor size, lymph node metastasis and stage were not correlated with COX-2 expression. Multivariate analysis for the factors associated with survival showed that serum CEA, size, depth and lymph node involvement correlated with survival, but COX-2 expression had no correlation.
Conclusion: These data suggest that COX-2 expression in primary lesion of colorectal cancer may not be a useful marker for evaluating prognosis. However, further studies are necessary for identification of the roles in colorectal
carcinogenesis.
키워드
COX-2;면역조직화학염색;결직장암
Cyclooxygenase-2 (COX-2);Colorectal cancer;Immunohistochemistry
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