유방암에서 DNA Topoisomerase Ⅱ-α와 E2F-1의 면역조직화학적 발현과 임상 및 병리학적 연관성
The Immunohistochemical Expression of DNA Topoisomerase Ⅱ-α and E2F-1 in the Breast Carcinoma and Their Relationship with Clinicopathologic Factors
김항윤, 김범규, 차성재, 임현묵, 박성준, 이태진,
소속 상세정보
김항윤 ( Kim Hang-Yun )
중앙대학교 의과대학 외과학교실
김범규 ( Kim Beom-Gyu )
중앙대학교 의과대학 외과학교실
차성재 ( Cha Sung-Jae )
중앙대학교 의과대학 외과학교실
임현묵 ( Lim Hyun-Muk )
중앙대학교 의과대학 외과학교실
박성준 ( Park Sung-Jun )
중앙대학교 의과대학 외과학교실
이태진 ( Lee Tae-Jin )
중앙대학교 의과대학 병리학교실
KMID : 0371320030640020093
Abstract
Purpose: Clinical courses of breast cancer are very different, and concern for finding a predictable marker of breast carcinomas has increased. This study focused on the relationship between the expressions of DNA topoisomerase Ⅱ-α as a proliferative marker, and E2F-1 as a transcription factor, with clinicopathological factors of infiltrating duct carcinomas of the breast.
Methods: We investigated the expressions of E2F-1 and DNA topoisomerase Ⅱ-α in 43 patients with infiltrating ductal carcinomas using immunohistochemical staining, and the results were analyzed with regard to clinicopathological
parameters.
Results: Among 43 infiltrating ductal carcinomas, 24 (55.8%) were immunohistochemically negative on E2F-1 and 19 (44.2%) were positive. The expression of E2F-1 correlated with increased tumor size, positive axillary lymph node metastasis and high stage. The topoisomerase Ⅱ-α index correlated with increased tumor size, positive lymph node metastasis, high stage, high histological grade and negative estrogen receptor. The expression of E2F-1 and the topo Ⅱ-α index were significantly correlated.
Conclusion: These results suggest that the expressions of DNA topoisomerase Ⅱ-α and E2F-1 play some role as prognostic factors for infiltrating duct carcinomas of the breast, but much more study will be required.
키워드
유방암;유방
Infiltrating ductal carcinoma;Breast;Topoisomerase Ⅱ-α;E2F-1
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