간세포암 환자에서 혈청 혈관내피세포성장인자와 종양의 미세 혈관 침범
Serum Vascular Endothelial Growth Factor (VEGF) and Microvessel Tumor Invasion in Hepatocellular Carcinomas
홍성우, 황동희, 백인욱, 이혁상,
소속 상세정보
홍성우 ( Hong Seong-Woo )
인제대학교 의과대학 서울백병원 외과학교실
황동희 ( Whang Dong-Hee )
인제대학교 의과대학 서울백병원 진단검사의학교실
백인욱 ( Paik In-Wook )
인제대학교 의과대학 서울백병원 외과학교실
이혁상 ( Lee Hyuck-Sang )
인제대학교 의과대학 서울백병원 외과학교실
KMID : 0371320030640030224
Abstract
PURPOSE: Vascular endothelial growth factor (VEGF) is a potent angiogenic factor in a number of cancers. The aim of this study was to evaluate the clinical significance of the serum level of VEGF in hepatocellular carcinoma (HCC) patients.
METHODS: Serum VEGF was measured by an enzyme linked immunosorbent assay (ELISA) method. The correlation between serum VEGF level and clinico-pathological data of HCC patients were evaluated.
RESULTS: The serum VEGF levels significantly increased with increasing tumor size and platelets count. The mean serum VEGF level in HCC patients with microvessel tumor invasion was higher than in those without microvessel tumor invasion.
CONCLUSION: A high serum VEGF level may be an indicator of tumor progression and an important predictor of microvessel tumor invasion.
키워드
혈관내피성장인자;간세포암;종양의 미세혈관 침범
Vascular endothelial growth factor;Hepatocellular carcinoma;Microvessel tumor invasion
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