갑상샘 종양에서 Thyroid Transcription Factor-1과 Ki-67의 발현
Expression of Thyroid Transcription Factor-1 and Ki-67 in the Thyroid Neoplasms
소속 상세정보
남상일/Nam SI
박성준/이태진/임현묵/차성재/김범규/Park SJ/Lee TJ/Lim HM/Cha SJ/Kim BK
KMID : 0371320030650010001
Abstract
Purpose: Thyroid transcription factor-1 (TTF-1) has been known to regulate the transcriptional activity of thyroid-specific genes. Ki-67 has been known as a marker for indicating tumor growth. This study was designed to campare the expressions of TTF-1 and Ki-67 on non-neoplastic and neoplastic thyroid tissues.
Methods: The surgically resected specimens of various histological types of thyroid tumor, from the files of the Dept. of surgery, Chung-Ang University Pil-Dong Hospital, between January 1998 and June 2002 were reviewed, and 55 cases selected for immunohistochemical studies. The materials consisted of tissues from 10 nodular hyperplasias, 28 papillary carcinomas, 15 follicular adenomas and 12 follicular carcinomas. All specimens were routinely processed, and paraffin blocks were available in all cases. Immunohistochemical strains for TTF-1 and Ki-67 were also performed.
Results: In all the cases, including the nodular hyperplasias, papillary carcinomas, follicular adenomas, and follicular carcinomas, expressions of the TTF-1 were observed. The properties of the TTF-1 expression, including staining intensity, extent and index were not related to the tumor type. The expression of TTF-1 was inversely correlated with the tumor proliferation fraction, as assessed by the Ki-67 staining index.
Conclusion: TTF-1 was expressed in almost all the benign lesions and well differentiated carcinomas, and correlated with the tumor proliferation fraction.
키워드
Thyroid neoplasms; Thyroid transcription; factor-1; Ki-67; 갑상샘암
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