췌담관암에서 술 전 및 술 후 CA-19-9 항원의 유용성에 대한 연구
Clinical usefulness of preoperative and postoperative CA-19-9 antigen in pancreatic and bile duct neoplasms
소속 상세정보
이형근/Lee HG
문현종/허진석/노재형/손태성/최성호/조재원/김용일/Moon HJ/Heo JS/Noh JH/Sohn TS/Choi SH/Joh JW/Kim YI
KMID : 0371320030650020145
Abstract
Purpose : The CA-19-9 antigen is a commonly used tumor marker for pancreatic and bile duct neoplasms, it is well known that the CA-19-9 antigen is a good predictor of respectability, prognosis and recurrence. The aim of this study was to evaluate the efficacy of the CA-19-9 antigen as preoperative respectability and postoperative recurrence markers in pancreatic and bile duct neoplasms.
Methods : Between February 1995 and June 2001, 234 patients, with pancreatic and bile duct neoplasms, at the Department of Surgery, Samsung Medical Center, were followed up with the CA-19-9 antigen, both preoperatively and postoperatively. The ROC curve was used to analyze the relationship between a radical resection and the preoperative CA-19-9 antigen. During the postoperative follow-up, 124 patients that had radical resections, and postoperative follow-up for the CA-19-9 antigen, were studied for this relationship using Chi-square tests.
Results : The cut-off values in the pancreatic (P=0.527) and bile duct (P=0.688) neoplasms were 325.50 U/ml and 58.35 U/ml, respectively, using the ROC curve for the relationship between a radical resection and the preoperative CA-19-9 antigen, although the result was statistically insignificant. From the 124 patients used for the statistical analysis, 64 had a recurrence, of which 57 showed an increase in the CA-19-9 antigen, with the 7 showing no elevation. 60 patients had no recurrence, of which 28 showed an increase in the CA-19-9 antigen. The elevation of the CA-19-9 antigen was analyzed between the recurrence and no recurrence groups using Chi-square tests, which revealed a statistical significance (P<0.001).
Conclusion : In patients with pancreatic and bile duct neopla는, the CA-19-9 antigen could not predict the preoperative respectability, but was a clinically effective follow-up marker for a recurrence. (J Korean Surg Soc 2003;65:145-149)
키워드
: CA-19-9 antigen; Pancreatic neoplasms; Bile duct neoplasms; CA-19-9 항원; 췌장암; 담관암
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