유방암에서 Cyclooxygenase-2 발현의 예후인자적 가치
Prognostic Value of Elevated Cyclooxygenase-2 Expression in Breast Cancer
설진원, 오기근, 김승일, 박찬흔, 박철재,
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설진원 ( )
한림대학교 의과대학 외과학교실
오기근 ( )
연세대학교 의과대학 병리학교실
김승일 ( )
한림대학교 의과대학 외과학교실
박찬흔 ( )
한림대학교 의과대학 외과학교실
박철재 ( )
한림대학교 의과대학 외과학교실
KMID : 0371320030650050377
Abstract
Purpose: Cyclooxygenase-2 (Cox-2) is the rate-limiting enzyme in the conversion of arachidonic acid to prostaglandins and can be induced by various agents such as growth factors and tumor promoters. Cox-2 contributes to carcinogenesis and tumor growth. This study was performed to demonstrate the correlation between elevated expression of Cox-2 and pathologic factors in breast cancer.
Methods: Cox-2 expression was analyzed immunohistochemically in paraffin-embedded tumor samples from 40 patients with breast cancer. Cox-2 expression was defined as negative or positive. The correlation between Cox-2 expression and pathologic factors (tumor size, axillary lymph node metastasis, TNM stage and histologic grade) was analyzed.
Results: Cox-2 was highly expressed in proportion to tumor size, but the difference was not significant (P>0.05). High Cox-2 expression was observed in the presence of axillary lymph node metastasis and TNM stage Ⅲ, but was not significant (P>0.05). The Cox-2 expression rate was significantly associated with high histologic grade (Ⅰ: 42.9%, Ⅱ:50.0%, Ⅲ:80.0%) (P=0.046).
Conclusion: Elevated levels of Cox-2 expression were associated with large tumor size, presence of axillary lymph node metastasis, high TNM stage and high histologic grade, and can therefore be a possible marker for poor prognosis. Due to the small number of cases, we couldn´t confirm the statistical significance except in terms of histologic grade. Further prospective studies with a large number of cases are required.
키워드
유방암;Cycloxygenase-2;예후인자;Breast cancer;Prognostic factors
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