방사성옥소 치료를 위해 입원한 중증 갑상선기능저하 상태의 분화갑상선암 환자에서 관찰되는 가역적 임상화학검사 변화 소견
Reversible Changes of Clinical Chemical Tests in Severe Hypothyroid Patients with Differentiated Thyroid Cancer Who Were Admitted for Radioiodine Therapy
정환정, 김창균, 이광만, 정수정, 송호천, 범희승,
소속 상세정보
정환정 ( Jeong Hwan-Jeong )
원광대학교 의과대학 핵의학교실
김창균 ( Kim Chang-Guhn )
원광대학교 의과대학 핵의학교실
이광만 ( Lee Kwang-Man )
원광대학교 의과대학 외과학교실
정수정 ( Jeong Soo-Jeong )
전남대학교 의과대학 핵의학교실
송호천 ( Song Ho-Chun )
전남대학교 의과대학 핵의학교실
범희승 ( Bom Hee-Seung )
전남대학교 의과대학 핵의학교실
KMID : 0371320040660010010
Abstract
Purpose: Severe hypothyroidism can cause abnormalities in numerous clinical chemical test results. We observed various reversible changes of clinical chemical test results in patients with severe hypothyroidism who were admitted for radioiodine abation therapy after total thyroidectomy. The purpose of this study was to describe and discuss the findings.
Methods: The study comprised 168 patients (24 males, 144 females, mean age 49±14 years) who underwent total thyroidectomy due to differentiated thyroid cancer and who were admitted for 1-131 ablation therapy. Patients who had hepatic or renal dysfunction were excluded.
Results: Serum mean levels of aspartate transaminase, alanine transaminase, cholesterol, high density lipoprotein, lactic dehydrogenase, total bilirubin, indirect bilirubin, and creatinine were significantly increased to the upper normal range during severe hypothyroid state (serum thyroid stimulating normone>30uIU/ml). While serum levels of alkaline phosphatase (ALP), triglyceride (TG) and blood urea nitrogen (BUN) remained unchanged. Six patients who showed abnormal serum creatinine level during hypothyroid condition returned to normal after recovery of thyroid function.
Conclusion: Results of clinical chemical tests for hepatic, lipid and renal function are often increased reversibly in severely hypothyroid patients. Reversible, abnormal serum creatinine levels may develop in some cases. Follow-up study is necessary in induced severely hypothyroid patients for radioiodine therapy to differentiate the reversibility of chemical tests.
키워드
중증 갑상선기능저하증;방사성옥소 치료;임상 화학 지표;Severe hypothyroidism;Radioiodine therapy;Clinical chemical test
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