GISTs에서 증가된 Ki67 Index (＞10%)와 p53 단백발현의 예후 인자로서의 유용성
Value of Elevated Ki67 Index (＞10%) and p53 Protein Expression as Prognostic Factors in GISTs
손보성, 전해명, 성기영, 진형민, 김욱, 박조현, 박승만, 임근우, 박우배, 김승남, 이교영,
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손보성 ( Sohn Bo-Sung )
가톨릭대학교 의과대학 여의도성모병원 외과학교실
전해명 ( Jeon Hae-Myung )
가톨릭대학교 의과대학 여의도성모병원 외과학교실
성기영 ( Sung Gi-Young )
가톨릭대학교 의과대학 여의도성모병원 외과학교실
진형민 ( Chin Hyung-Min )
가톨릭대학교 의과대학 여의도성모병원 외과학교실
김욱 ( Kim Wook )
가톨릭대학교 의과대학 여의도성모병원 외과학교실
박조현 ( Park Cho-Hyun )
가톨릭대학교 의과대학 여의도성모병원 외과학교실
박승만 ( Park Seung-Man )
가톨릭대학교 의과대학 여의도성모병원 외과학교실
임근우 ( Lim Keun-Woo )
가톨릭대학교 의과대학 여의도성모병원 외과학교실
박우배 ( Park Woo-Bae )
가톨릭대학교 의과대학 여의도성모병원 외과학교실
김승남 ( Kim Seung-Nam )
가톨릭대학교 의과대학 여의도성모병원 외과학교실
이교영 ( Lee Kyo-Young )
가톨릭대학교 의과대학 여의도성모병원 임상병리학교실
KMID : 0371320040660020098
Abstract
Purpose: Although gastrointestinal stromal tumors (GISTs) are the most common mesenchymal tumors and express CD117, the prediction of their malignant potential remains difficult. The aim of this study is to evaluate the prognostic accuracy of elevated Ki67 index and p53 overexpression in combination with classical prognostic factors (tumor size and mitotic index).
Methods: A retrospective study was conducted in 84 patients who had been re-evaluated for confirmation of diagnosis based on immunohistochemical analysis with CD117 expression between Jan 1991 and Dec 2001. Cases were classified as very low, low, intermediate and high-risk groups according to 2001 NIH consensus symposium. Elevated Ki67 index was assigned to the lesion that displayed 10% or more of immunoreactive cells. And p53 expression was assigned to the area with 5% or more of eosinophilic nucleus.
Results: Elevated Ki67 was noted in 37 (44.0%) out of 84 cases. High-risk patients showed elevated Ki67 index more frequently (P<0.0001) and there was significant relation between elevated Ki67 and survival rate (P=0.0417). The p53 expression was noted in 32 (38.1%) out of 84 cases. The p53 expression was significantly higher in high-risk patients (P=0.0081) than low-risk patients. But, there was no significant relation between p53 expression and survival rate. As a result of multivariate analysis, tumor size (P=0.0059), mitotic index (P=0.0016) and elevated Ki67 index (P=0.0384) were proved as significant independent prognostic factors.
Conclusion: According to the results of our retrospective study, p53 expression is related to disease progression but its value as a prognostic factor in GISTs is uncertain. It is suggested that tumor size, mitotic rate and elevated Ki67 index are the helpful prognostic factors in GISTs.
키워드
예후;Ki67 증식지수;p53:위장관 간질종양;Prognosis;Ki67 index;GISTs
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