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Outcome of Curative Resection in Patients with Completely Obstructing Colorectal Cancer
ÀÌ°È«, À¯Ã¢½Ä, ±èÈñö, ±èÁ¤¶û, ±è¿µ¹Î, ±èÁ¤¼±, ±èÁøõ,
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ÀÌ°È« ( Lee Kang-Hong )
¿ï»ê´ëÇб³ ÀÇ°ú´ëÇÐ ¿Ü°úÇб³½Ç
À¯Ã¢½Ä ( Yu Chang-Sik )
¿ï»ê´ëÇб³ ÀÇ°ú´ëÇÐ ¿Ü°úÇб³½Ç
±èÈñö ( Kim Hee-Cheol )
¿ï»ê´ëÇб³ ÀÇ°ú´ëÇÐ ¿Ü°úÇб³½Ç
±èÁ¤¶û ( Kim Jung-Rang )
¿ï»ê´ëÇб³ ÀÇ°ú´ëÇÐ ¿Ü°úÇб³½Ç
±è¿µ¹Î ( Kim Young-Min )
¿ï»ê´ëÇб³ ÀÇ°ú´ëÇÐ º´¸®Çб³½Ç
±èÁ¤¼± ( Kim Jung-Sun )
¿ï»ê´ëÇб³ ÀÇ°ú´ëÇÐ º´¸®Çб³½Ç
±èÁøõ ( Kim Jin-Cheon )
¿ï»ê´ëÇб³ ÀÇ°ú´ëÇÐ ¿Ü°úÇб³½Ç
KMID : 0371320040660030199
Abstract
Purpose: A large bowel obstruction as a result of primary colorectal cancer has a poor outcome. A retrospective study was designed to verify the recurrence patterns and to determine the prognostic factors after a curative resection in patients with a completely obstructing colorectal cancer.
Methods: Eight hundred patients with stage ¥± and ¥² colorectal adenocarcinomas (37 patients with a complete obstruction and 763 patients without an obstruction) underwent curative surgery between 1989 and 1996 at the Asan Medical Center. The median follow-up period was 55 (3~107) months.
Results: Clinicopathologic variables, i.e. sex, serum carcino-embryonic antigen (CEA), Borrmann type, differentiation, and tumor stage in the two groups were similar. Patients with obstructing colorectal cancer were significantly older than those without an obstruction (61¡¾14 vs. 56¡¾12 years, P=0.02). Rectal cancers were more frequent in the non-obstructing cancers than in the obstructing cancers (P=0.02). The recurrence rate in the two groups was similar (obstructing vs. non-obstructing cancer, 27.0% vs. 28.0%). Ten patients with 12 recurrences were identified in 37 obstructing ¥álorectal cancer patients, three with local recurrences (8.1%) and nine with distant metastasis (24.3%). The 5-year survival rate between the same stages was not different between the two groups (77.8% vs. 85.3% in stage ¥±, 65.1% vs. 60.4% in stage ¥²). Among the various clinicopathologic variables, neural invasion was strongly associated with a poor prognosis in obstructing colorectal cancer on multivariate analysis (P<0.05).
Conclusion: Because the obstructing cancers and the non-obstructing colorectal cancers had a similar outcome, curative surgery appears to offer the best chance of a cure in stage ¥± and ¥² obstructing colorectal cancer.
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Æм⼺ ´ëÀå¾Ï;Àç¹ß;¿¹ÈÄ;Obstruction;Colorectal cancer;Recurrence;Prognosis
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