침윤성 유방암에서 PTEN 단백 발현과 다른 예후인자들과의 관계
Expression of the PTEN Gene Product in the Invasive Cancer of Breast and Its Relationship with Other Prognostic Factors
정귀애, 이미자, 김병철, 전호종, 민영돈, 김성환, 김권천,
소속 상세정보
정귀애 ( Jeong Gui-Ae )
조선대학교 의과대학 외과학교실
이미자 ( Lee Mi-Ja )
조선대학교 의과대학 병리학교실
김병철 ( Kim Byung-Chul )
조선대학교 의과대학 외과학교실
전호종 ( Jeon Ho-Jong )
조선대학교 의과대학 병리학교실
민영돈 ( Min Young-Don )
조선대학교 의과대학 외과학교실
김성환 ( Kim Seong-Hwan )
조선대학교 의과대학 외과학교실
김권천 ( Kim Kweon-Cheon )
조선대학교 의과대학 외과학교실
KMID : 0371320040660040289
Abstract
Purpose: The tumor suppressor gene PTEN is located on chromosome 10q23 and is mutated in a variety of sporadic cancers. The aim of this study is to understand the expression of the PTEN gene product in invasive breast cancer and its relationships with clinicopathologic factors of breast cancer.
Methods: The hospital records and pathologic findings of 57 patients who underwent breast operation due to invasive breast carcinoma between January 1996 and June 2002 were reviewed. We examined the relationships between PTEN expression and various clinicopathologic factors of breast cancer such as age, tumor size, lymph node metastasis, histologic grade, nuclear grade, stage and estrogen, and progesterone receptors.
Results: Among the 57 invasive breast cancers, 5 (8.8%) were immunohistochemically negative, and 14 (24.6%) had reduced expression of PTEN. Among clinicopathologic factors, age, tumor size, lymph node metastasis, stage, histologic grade, and estrogen receptor had no correlation with PTEN expression. Nuclear grade and positive progesterone receptor were significant correlated with decreased PTEN expression, However, these results are different from those of other reports showing that negative progesterone receptor was significantly correlated with the decrease of PTEN expression.
Conclusion: According to other reports, PTEN expression does play some role as a prognostic factor for breast cancer, but the results of our study did not support this hypothesis. Further evaluation and study are required into the role of PTEN as a prognostic factor of breast cancer.
키워드
유방암;PTEN;예후인자;Breast cancer;Prognostic factor
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