위선암에서 Cyclin B1과 D1 단백발현이 임상병리학적 예후인자와 생존율에 미치는 영향
The Influence of Expressions of Cyclin B1 and D1 on Clinicopathologic Prognostic Factors and Survival Rate in Gastric Cancer
강기창, 박언섭, 박용검, 지경천, 이정효, 장인택, 박성일,
소속 상세정보
강기창 ( Kang Gi-Chang )
중앙대학교 의과대학 외과학교실
박언섭 ( Park Eon-Sub )
중앙대학교 의과대학 병리학교실
박용검 ( Park Yong-Gum )
중앙대학교 의과대학 외과학교실
지경천 ( Chi Kyong-Chon )
중앙대학교 의과대학 외과학교실
이정효 ( Lee Jung-Hyo )
중앙대학교 의과대학 외과학교실
장인택 ( Chang In-Taek )
중앙대학교 의과대학 외과학교실
박성일 ( Park Sung-Il )
중앙대학교 의과대학 외과학교실
KMID : 0371320040670010025
Abstract
PURPOSE: Disturbance in normal cell cycles by cell cycle control factors is an important process of cancer carcinogenesis. The aims of this dissertation were identify the influence of cyclin B1 and D1 on the growth and expression of gastric cancer and their effects on the prognosis.
METHOD: The subjects were 128 patients selected from those who underwent gastric surgery for their gastric cancer between January 1995 and December 1998. Immunohistochemical staining was conducted for cyclin B1 and D1 using paraffin embedded tissues, followed by analysis of their protein expressions, possible prognostic factors and survival rate.
RESULTS: Cyclin B1 expression was founded in 48 of the 128 patients (37.5%), and that of cyclin D1 in 96 (75%). Both cyclin B1 and D1 showed no statistical significance with T-stage, location of tumors or histologic types. However, for the case of any significance with lymph node metastasis, the higher the N-stage, the greater was the expression of cyclin B1 (P=0.014). For the case of any significance with life term, the Kaplan-Meier method showed the greater the expression of cyclin B1, the shorter the life term (P=0.042).
CONCLUSION: An association was indicated between cyclin B1 and lymph node metastasis in gastric cancer, but has no relation with the T-stage, histologic type or location of tumors. Cyclin D1 shows no association with lymph node metastasis, T-stage, histologic type or location of tumors. However, cyclin B1 showed a significant association with the survival rate.
키워드
위암;싸이클린 B1;싸이클린 D1;예후인자;Gastric cancer;Cyclin B1;Cyclin D1;Prognostic factor
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