대장암의 Fas매개 세포 사멸에서 cFLIP(L)의 역할
Roles of cFLIPL in Fas-mediated Apoptosis of Colon Cancer
김용호, 윤충, 박재훈,
소속 상세정보
김용호 ( Kim Yong-Ho )
울산대학교 의과대학 강릉아산병원 외과
윤충 ( Yoon Choong )
경희대학교 의과대학 외과학교실
박재훈 ( Park Jae-Hoon )
경희대학교 의과대학 병리학교실
KMID : 0371320040670010047
Abstract
PURPOSE: Substantial numbers of the colon cancer cells have been observed to express Fas/Fas ligands, but are resistant to Fas-mediated apoptosis, suggesting that colon tumors might develop the specific mechanisms to overcome Fas-mediated apoptosis. Recently, cellular FLICE-like inhibitory protein (cFLIP) has been identified as an endogenous inhibitor of Fas- or other receptor-mediated apoptosis and its altered high expression has been suspected to be associated with tumor development or progression. This study investigated the prevalence of cFLIPL alterations in colon carcinomas and possible implications in the progression of colon cancers.
METHODS: In order to investigate the function of cFLIPL for the development and progression of the colon cancer, we analyzed the expression of the cFLIPL in 58 colon cancer and 6 colon cancer cell lines.
RESULTS: The study results demonstrated that cFLIPL is one of the major determinants for sensitivity to Fas-mediated apoptosis in colon cancer cell lines. In addition, we analyzed cFLIPL expression in 58 cases of adenocarcinoma of the colon and showed that cFLIPL, expression was increased in adenocarcinoma as compared to matched normal mucosa.
CONCLUSION: Taken together, our data strongly suggested that abnormal overexpression of cFLIPL is a frequent event in colon carcinomas and might contribute to in vivo tumor transformation.
키워드
대장암 세포주; 세포 사멸; Colon cancer cell lines; cFLIPL; Apoptosis; Fas
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