담석증, 급성 담낭염, 담도염 환자의 Nitrate/Nitrite (NOx)의 측정치와 질병의 중등도와의 관계
Correlation of the Serum Nitrate/Nitrite Level with the Severity of Biliary Tract Inflammation
최경호, 김해성, 최연승, 조응호, 안승익, 이건영, 홍기천, 최선근, 허윤석, 김세중, 우제홍, 신석환, 차석호, 차영남,
소속 상세정보
최경호 ( Choi Kyong-Ho )
인하대학교병원 외과학교실
김해성 ( Kim Hae-Sung )
인하대학교 의과대학 외과학교실
최연승 ( Choi Yun-Seung )
인하대학교 의과대학 외과학교실
조응호 ( Cho Eung-Ho )
인하대학교 의과대학 외과학교실
안승익 ( Ahn Seung-Ick )
인하대학교 의과대학 외과학교실
이건영 ( Lee Kun-Young )
인하대학교 의과대학 외과학교실
홍기천 ( Hong Kee-Chun )
인하대학교 의과대학 외과학교실
최선근 ( Choi Sun-Keun )
인하대학교 의과대학 외과학교실
허윤석 ( Heo Yoon-Seok )
인하대학교 의과대학 외과학교실
김세중 ( Kim Sei-Joong )
인하대학교 의과대학 외과학교실
우제홍 ( Woo Ze-Hong )
인하대학교 의과대학 외과학교실
신석환 ( Shin Suk-Hwan )
인하대학교 의과대학 외과학교실
차석호 ( Cha Seok-Ho )
인하대학교 의과대학 약리학교실
차영남 ( Cha Young-Nam )
인하대학교 의과대학 약리학교실
KMID : 0371320040670010055
Abstract
PURPOSE: The relationship between the biophysical and biochemical processes of gallbladder bile and nitric oxide is still not well known. In this study, the correlation between nitric oxide production and the degree of biliary tract inflammation was investigated and the levels of nitrate/nitrite (NOx) and stable metabolite of nitric oxide in the serum proposed for assessing the severity of biliary tract inflammation.
METHODS: Eighty two patients with biliary tract inflammation who underwent operative treatment between March and July 2002 were included in this study. Of the 82 patients, there were 31 and 51 men and women, respectively. The mean age was 53, ranging from 21 to 82 years. The subjects were divided into three groups, GB stone (n=42), and acute cholecystitis (n=27), and cholangitis (n= 13). The severity of biliary tract inflammation was assessed using the WBC count, total bilirubin count, GB wall thickness on pathology, bile duct stone detected on ultrasonography, open conversion of cholecystectomy, pyrexia and tenderness/rebound tenderness on physical examination. The serum NOx concentrations were analyzed according to the groups, clinicopathological, laboratory and radiological findings. The serum NOx levels were measured using the Griess reaction after conversion of all nitrates to nitrites.
RESULTS: The nitrate/nitrite levels in the GB, acute cholecystitis and cholangitis groups were 70.0+/-44.6, 126.8+/-54.5 and 142.0+/-44.6mumol/L, respectively, with statistical differences between the three groups (P< 0.05). The NOx level in patients with pyrexia, hyperbilirubinemia, leukocytosis, GB wall thickness on pathology and open conversion were markedly increased compared with the control group (P<0.05). These data demonstrate the relationship between the intensity of nitric oxide and the severity of biliary tract inflammation.
CONCLUSION: Measurement of the NOx concentration in patients with biliary tract inflammation provides information about the severity and course of the disease. These results suggest there is a correlation between nitric oxide and the degree of biliary tract inflammation.
키워드
산화 질소;담낭;담석;담낭염;담도염;Nitric oxide;Gallbladder;GB stone;Cholecystitis;Cholangitis
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