Prognostic significance of cytosolic phospholipase A2 expression in patients with colorectal cancer
유영선, 임성철, 김경종,
소속 상세정보
유영선 ( Yoo Young-Sun )
Chosun University College of Medicine Department of Surgery
임성철 ( Lim Sung-Chul )
Chosun University College of Medicine Department of Pathology
김경종 ( Kim Kyung-Jong )
Chosun University College of Medicine Department of Surgery
KMID : 0371320110800060397
Abstract
Purpose: Cyclooxygenase-2 is believed to be an important enzyme in the pathogenesis of colorectal cancer (CRC). Cytosolic phospholipase A2 (cPLA2), also, have been suggested to be related to the carcinogenesis of CRC. The aim of this study was to investigate cPLA2 expression and its relationship with prognostic significance in CRC.
Methods: Eighty-eight patients with colorectal cancer who underwent curative surgery were enrolled in this study. cPLA2 was examined in 88 primary CRCs by immunohistochemistry and we compared their expression with clinicopathologic findings, recurrence and survival in patients with CRC.
Results: The expression of cPLA2 was positive in 54.5% (48/88). The expression of cPLA2 was not correlated with clinicopathologic parameters. However, cPLA2 expression was significantly related with vascular endothelial growth factor expression. Kaplan-Meier analysis didn’t show any clinical significance in disease-free survival and overall survival according to cPLA2 expression.
Conclusion: These results suggest that cPLA2 expression was not associated with the prognosis of CRC. However, further large-scale studies are needed to clarify the prognostic effect of cPLA2 in CRC.
키워드
Cytosolic phospholipase A2; Prognosis; Colorectal cancer
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