Primary thyroid mucosa-associated lymphoid tissue lymphoma; a clinicopathological study of seven cases
이승철, 홍순원, 이용상, 정종주, 남기현, 정웅윤, 장항석, 박정수,
소속 상세정보
이승철 ( Lee Seung-Chul )
Hallym University College of Medicine Department of Surgery
홍순원 ( Hong Soon-Won )
Yonsei University College of Medicine Department of Pathology
이용상 ( Lee Yong-Sang )
Yonsei University College of Medicine Department of Surgery
정종주 ( Jeong Jong-Ju )
Yonsei University College of Medicine Department of Surgery
남기현 ( Nam Kee-Hyun )
Yonsei University College of Medicine Department of Surgery
정웅윤 ( Chung Woong-Youn )
Yonsei University College of Medicine Department of Surgery
장항석 ( Chang Hang-Seok )
Yonsei University College of Medicine Department of Surgery
박정수 ( Park Cheong-Soo )
Yonsei University College of Medicine Department of Surgery
KMID : 0371320110810060374
Abstract
Purpose: Primary thyroid mucosa-associated lymphoid tissue (MALT) lymphoma is a very rare subgroup of thyroid lymphoma, accounting for about 6 to 28% of all primary thyroid lymphomas. The purpose of this study was to evaluate its clinicopathological features and treatment outcomes.
Methods: We identified seven patients with thyroid MALT lymphoma who were treated between January 1997 and December 2007, and reviewed their clinicopathological features and follow-up outcomes.
Results: There were five female and two male patients, and their mean age was 73 years. All patients presented with palpable neck mass. Two patients had hoarseness and dyspnea. All patients had a history of Hashimoto’s thyroiditis with a mean of 175 months. Malignant lymphoma was suspected in only three patients using core needle biopsy. Four patients underwent thyroidectomy in the absence of preoperative pathologic confirmation, and histologic diagnosis was obtained after surgery. As initial treatment, complete surgical resection was performed in five patients, radiotherapy in one, and a combination of chemotherapy and radiotherapy in one. Six patients were alive for the mean follow-up period of 66 months and one patient died of unrelated causes. There were neither recurrences nor disease-specific mortalities.
Conclusion: When primary thyroid MALT lymphoma occurs in the thyroid or is confined to the neck, it responds well to local treatment such as surgical resection and external beam radiation therapy.
키워드
Primary thyroid MALT lymphoma; Hashimoto’s thyroiditis; Diffuse large B-cell lymphoma
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