Carcinoembryonic antigen level of draining venous blood as a predictor of recurrence in colorectal cancer patient
이수영, 민경선, 정중기, 정인묵, 안영준, 황기태, 안혜성, 허승철,
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이수영 ( Lee Soo-Young )
Seoul National University Boramae Medical Center Department of Surgery
민경선 ( Min Kyung-Sun )
Seoul National University Hospital Department of Nuclear Medicine
정중기 ( Chung Jung-Kee )
Seoul National University College of Medicine Department of Surgery
정인묵 ( Jung In-Mok )
Seoul National University Boramae Medical Center Department of Surgery
안영준 ( Ahn Young-Joon )
Seoul National University Boramae Medical Center Department of Surgery
황기태 ( Hwang Ki-Tae )
Seoul National University Boramae Medical Center Department of Surgery
안혜성 ( Ahn Hye-Seong )
Seoul National University Boramae Medical Center Department of Surgery
허승철 ( Heo Seung-Chul )
Seoul National University Boramae Medical Center Department of Surgery
KMID : 0371320110810060387
Abstract
Purpose: We designed this study to evaluate the efficacy of carcinoembryonic antigen in draining venous blood (vCEA) as a predictor of recurrence.
Methods: Draining venous and supplying arterial bloods were collected separately during the operation of 82 colorectal cancer patients without distant metastasis from September 2004 to December 2006. Carcinoembryonic antigen was measured and assessed for the efficacy as a prognostic factor of recurrence using receiver operating characteristic (ROC) and Kaplan-Meier curves.
Results: vCEA is a statistically significant factor that predicts recurrence (P = 0.032) and the optimal cut-off value for vCEA from ROC curve is 8.0 ng/mL. The recurrence-free survival between patients with vCEA levels >8 ng/mL and ≤8 ng/mL significantly differed (P < 0.001). The significance of vCEA as a predictor of recurrence gets higher when limited to patients without lymph node metastasis. The proper cut-off value for vCEA is 4.0 ng/mL if confined to patients without lymph node metastasis. The recurrence-free survival between the patients of vCEA levels >4 ng/mL and ≤4 ng/mL significantly differed (P < 0.001). Multivariate analysis revealed vCEA is an independent prognostic factor in patients without lymph node metastasis.
Conclusion: vCEA is an independent prognostic factor of recurrence in colorectal cancer patients especially in patients without lymph node metastases.
키워드
Colorectal neoplasms; Carcinoembryonic antigen; Prognosis; Recurrence
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