Factors affecting long-term survival after surgical resection of pancreatic ductal adenocarcinoma
윤경원, 허진석, 최동욱, Choi Seoung-Ho,
소속 상세정보
윤경원 ( Yoon Kyoung-Won )
Sungkyunkwan University School of Medicine Department of Surgery
허진석 ( Heo Jin-Seok )
Sungkyunkwan University School of Medicine Samsung Medical Center Department of Surgery
최동욱 ( Choi Dong-Wook )
Sungkyunkwan University School of Medicine Samsung Medical Center Department of Surgery
( Choi Seoung-Ho )
Sungkyunkwan University School of Medicine Department of Surgery
KMID : 0371320110810060394
Abstract
Purpose: Some patients who undergo surgical resection of pancreatic cancer survive longer than other patients. The purpose of this study was to identify the factors that affect long-term survival after resection of histopathologically confirmed pancreatic ductal adenocarcinoma.
Methods: A single-center, retrospective study was conducted among 164 patients who underwent surgical resection of pancreatic cancer, between May 1995 and December 2004. The patient follow-up process was conducted via telephone survey and review of electronic medical records for at least 5 years or until death.
Results: We compared patients with long-term (≥60 months, n = 19) and short-term survival (<60 months, n = 145). Resection margin status, differentiation of the tumor, tumor stage, pre-operative serum level of albumin, total bilirubin and carbohydrate antigen (CA) 19-9 level are related with survival difference (all factors, P < 0.05). Multivariate analysis revealed that a pre-operative serum total bilirubin level <7 mg/dL and a pre-operative serum CA19-9 level <37 U/mL is a statistically significant prognostic factor for long-term survival.
Conclusion: The preoperative serum total bilirubin and serum CA19-9 levels are associated with long-term survival after surgical resection of pancreatic cancer.
키워드
Pancreatic neoplasms; Bilirubin; CA19-9 antigen
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