Amylase, lipase, and volume of drainage fluid in gastrectomy for the early detection of complications caused by pancreatic leakage
서경원, 윤기영, 이상호, Shin Yeon-Myung, 최경현, 황현용,
소속 상세정보
서경원 ( Seo Kyung-Won )
Kosin University College of Medicine Department of Surgery
윤기영 ( Yoon Ki-Young )
Kosin University College of Medicine Department of Surgery
이상호 ( Lee Sang-Ho )
Kosin University College of Medicine Department of Surgery
( Shin Yeon-Myung )
Kosin University College of Medicine Department of Surgery
최경현 ( Choi Kyung-Hyun )
Kosin University College of Medicine Department of Surgery
황현용 ( Hwang Hyun-Yong )
Kosin University College of Medicine Department of Laboratory
KMID : 0371320110810060402
Abstract
Purpose: Pancreatic leakage is a serious complication of gastrectomy due to stomach cancer. Therefore, we analyzed amylase and lipase concentrations in blood and drainage fluid, and evaluated the volume of drainage fluid to discern their usefulness as markers for the early detection of serious pancreatic leakage requiring reoperation after gastrectomy.
Methods: From January 2001 to December 2007, we retrospectively analyzed data from 24,072 patient samples. We divided patients into two groups; 1) complications with pancreatic leakage (CG), and 2) no complications associated with pancreatic leakage (NCG). Values of amylase and lipase in the blood and drainage fluid, volume of the drainage fluid, and relationships among the volumes, amylase values, and lipase values in the drainage fluid were evaluated, respectively in the two groups.
Results: The mean amylase values of CG were significantly higher than those of NCG in blood and drainage fluid (P < 0.05). For lipase, statistically significant differences were observed in drainage fluid (P < 0.05). The mean volume (standard deviation) of the drained fluid through the tube between CG (n = 22) and NCG (n = 236) on postoperative day 1 were 368.41 (266.25) and 299.26 (300.28), respectively. There were no statistically significant differences between the groups (P = 0.298). There was a correlation between the amylase and lipase values in the drainage fluid (r = 0.812, P = 0.000).
Conclusion: Among postoperative amylase and lipase values in blood and drainage fluid, and the volume of drainage fluid, the amylase in drainage fluid was better differentiated between CG and NCG than other markers. The volume of the drainage fluid did not differ significantly between groups.
키워드
Drainage fluid; Pancreatic leakage; Stomach neoplasms; Gastrectomy
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