Interstitial lung disease caused by TS-1: a case of long-term drug retention as a fatal adverse reaction
박중민, 황인규, 서석원, 지경천,
소속 상세정보
박중민 ( Park Joong-Min )
Chung-Ang University College of Medicine Department of Surgery
황인규 ( Hwang In-Gyu )
Chung-Ang University College of Medicine Department of Internal Medicine
서석원 ( Suh Suk-Won )
Chung-Ang University College of Medicine Department of Surgery
지경천 ( Chi Kyong-Choun )
Chung-Ang University College of Medicine Department of Surgery
KMID : 0371320110810060414
Abstract
TS-1 is an oral anti-cancer agent for gastric cancer with a high response rate and low toxicity. We report a case of long-term drug retention of TS-1 causing interstitial lung disease (ILD) as a fatal adverse reaction. A 65-year-old woman underwent a total gastrectomy with pathologic confirmation of gastric adenocarcinoma. She received 6 cycles of TS-1 and low-dose cisplatin for post-operative adjuvant chemotherapy followed by single-agent maintenance therapy with TS-1. After 8 months, the patient complained of a productive cough with sputum and mild dyspnea. A pulmonary evaluation revealed diffuse ILD in the lung fields, bilaterally. In spite of discontinuing chemotherapy and the administration of corticosteroids, the pulmonary symptoms did not improve, and the patient died of pulmonary failure. TS-1-induced ILD can be caused by long-term drug retention that alters the lung parenchyma irreversibly, the outcome of which can be life-threatening. Pulmonary evaluation for early detection of disease is recommended.
키워드
TS-1; Interstitial lung diseases; Stomach neoplasms; Adverse reaction
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