The effectiveness of postoperative neutrophils to lymphocytes ratio in predicting long-term recurrence after stomach cancer surgery
김윤홍, 최원준,
소속 상세정보
김윤홍 ( Kim Yun-Hong )
Sungkyunkwan University School of Medicine Kangbuk Samsung Hospital Department of Anesthesiology and Pain Medicine
최원준 ( Choi Won-Joon )
Sungkyunkwan University School of Medicine Kangbuk Samsung Hospital Department of Anesthesiology and Pain Medicine
KMID : 0371320120830060352
Abstract
Purpose: Immunosuppression is a characteristic of cancer recurrence after curative resection. The neutrophil to lymphocyte ratio (NL ratio) in peripheral blood is associated with immune function. However, it is not clear whether the postoperative NL ratio is a predictor for cancer relapse after resection. Thus, we investigated the effectiveness of the short-term postoperative NL ratio in the prediction of disease recurrence within 5 years after stomach cancer surgery by a retrospective chart review. Methods: Ninety-three patients with stomach cancer were enrolled. Significant risk factors for cancer recurrence were determined by multivariate Cox regression. Independent variables to increase the NL ratio to ＞7.7 by postoperative day (POD) 3 were examined by multivariate logistic regression analysis. Results: The 5-year risk of cancer recurrence after gastrectomy was 4.2 times higher for patients with a POD3 NL ratio of ＞7.7 (P = 0.005), 3.4 times higher for normal-weight patients compared with overweight patients (P = 0.008), and 20 times higher for stage III compared with stage 0 according to the tumor-node-metastasis cancer staging system (P = 0.003). The surgical duration (hours) increased the chance of high NL ratio ＞7.7 (odds ratio, 2.5; P = 0.006). Conclusion: The postoperative NL ratio, especially the POD3 NL ratio, predicts long-term recurrence after stomach cancer surgery.
키워드
Immunosuppression; Lymphocyte; Neoplasm recurrence; Neutrophil
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