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Lactate/albumin ratio for the prediction of the development of sepsis-induced acute kidney injury in the emergency department
ÀÌÁ¤¿ì, À¯Á¦¼º, Á¤¼ºÇÊ, Á¹ÎÈ«, °øÅ¿µ, °íµ¿·ü, ȲÀ±Á¤, ÀÌ¿ëÈñ, ¹ÚÀÎö, ±è½Ã³»,
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ÀÌÁ¤¿ì ( Lee Jeong-Woo )
¿¬¼¼´ëÇб³ ÀÇ°ú´ëÇÐ ÀÀ±ÞÀÇÇб³½Ç
À¯Á¦¼º ( You Je-Sung )
¿¬¼¼´ëÇб³ ÀÇ°ú´ëÇÐ ÀÀ±ÞÀÇÇб³½Ç
Á¤¼ºÇÊ ( Chung Sung-Phil )
¿¬¼¼´ëÇб³ ÀÇ°ú´ëÇÐ ÀÀ±ÞÀÇÇб³½Ç
Á¹ÎÈ« ( Choa Min-Hong )
¿¬¼¼´ëÇб³ ÀÇ°ú´ëÇÐ ÀÀ±ÞÀÇÇб³½Ç
°øÅ¿µ ( Kong Tae-Young )
¿¬¼¼´ëÇб³ ÀÇ°ú´ëÇÐ ÀÀ±ÞÀÇÇб³½Ç
°íµ¿·ü ( Ko Dong-Ryul )
¿¬¼¼´ëÇб³ ÀÇ°ú´ëÇÐ ÀÀ±ÞÀÇÇб³½Ç
ȲÀ±Á¤ ( Hwang Yoon-Jung )
¿¬¼¼´ëÇб³ ÀÇ°ú´ëÇÐ ÀÀ±ÞÀÇÇб³½Ç
ÀÌ¿ëÈñ ( Lee Yong-Hee )
¿¬¼¼´ëÇб³ ÀÇ°ú´ëÇÐ ÀÀ±ÞÀÇÇб³½Ç
¹ÚÀÎö ( Park In-Cheol )
¿¬¼¼´ëÇб³ ÀÇ°ú´ëÇÐ ÀÀ±ÞÀÇÇб³½Ç
±è½Ã³» ( Kim Si-Nae )
¿¬¼¼´ëÇб³ ÀÇ°ú´ëÇÐ ¿¬±¸ºÎ Åë°èÁö¿øÆÀ
KMID : 0385920190300010022
Abstract
Objective: The early prediction of acute kidney injury (AKI) in sepsis and the provision of prompt treatment may improve the outcomes. This study investigated the efficacy of the lactate/albumin ratio (LAR) in predicting severe AKI in cases of septic shock.
Method: This retrospective, observational cohort study was performed on patients integrated prospectively in a critical pathway of early-goal-directed therapy (EGDT)/SEPSIS. Adult patients with septic shock, who were admitted to the emergency department with a normal kidney function or stage 1 disease based on the Acute Kidney Injury Network classification between January 1, 2014 and September 30, 2017, were analyzed. The outcomes were the development of sepsis-induced severe AKI within 7 days.
Results: A total of 343 patients were enrolled. An increase in the LAR value at admission (odds ratio [OR], 1.85; P=0.001) was a strong independent predictor of the development of severe AKI. The increasing predictability of AKI was closely associated with a L/A ratio¡Ã0.794 at admission (OR, 14.66; P<0.001). The area under the receiver operating characteristic curve value of the L/A ratio (0.821; 95% confidence interval [CI], 0.774-0.861; P<0.01) was higher than that of lactate (0.795; 95% CI, 0.747-0.838; P<0.01) for predicting severe AKI (P=0.032).
Conclusion: L/A ratio was found to be an independent predictor of the development of severe AKI in septic shock. The prognostic performance of the L/A ratio for predicting AKI of critically ill sepsis patients was superior to that of lactate measurements.
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Sepsis; Acute kidney injury; Lactic acid; Albumins; Prognosis
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