어린 영아의 중증 세균성 감염 진단에 젖산 측정의 효용성
Utility of lactate measurement in the diagnosis of serious bacterial infection in young infants
김진혁, 이동욱, 문형준, 김도의, 이현정, 정동길, 조성필, 김현준, 이정원, 최재형,
소속 상세정보
김진혁 ( Kim Jin-Hyeok )
순천향대학교 천안병원 응급의학과
이동욱 ( Lee Dong-Wook )
순천향대학교 천안병원 응급의학과
문형준 ( Moon Hyung-Jun )
순천향대학교 천안병원 응급의학과
김도의 ( Kim Do-Eui )
순천향대학교 천안병원 응급의학과
이현정 ( Lee Hyun-Jung )
순천향대학교 천안병원 응급의학과
정동길 ( Jung Dong-Kil )
순천향대학교 천안병원 응급의학과
조성필 ( Jo Sung-Pill )
순천향대학교 천안병원 응급의학과
김현준 ( Kim Hyun-Joon )
순천향대학교 천안병원 응급의학과
이정원 ( Lee Jung-Won )
건국대학교 충주병원 응급의학과
최재형 ( Choi Jae-Hyung )
건국대학교 충주병원 응급의학과
KMID : 0385920200310010105
Abstract
Objective: Serious bacterial infection (SBI) is a common disease among infants, and it is associated with high morbidity and mortality. Making the diagnosis of SBI is challenging and measurement of various biomarkers is useful. This study examined the utility of lactate at an emergency department for diagnosing SBI patients.
Method: This was a retrospective, observational study of febrile infants less than 90 days old presenting to the emergency department of a tertiary hospital between September 2014 and August 2017. The demographic and laboratory data was collected through a chart review.
Results: Laboratory tests such as the white blood cell count, C-reactive protein (CRP), procalcitonin, and lactate showed significant differences on the Student-T test and the Mann Whitney-U test. Multivariabe logistic regression test was done using the variables with significant differences. CRP (P=0.037; odds ratio, 1.01), procalcitonin (P=0.011; odds ratio, 1.02) and lactate (P=0.001; odds ratio, 2.38) shows significant correlation.
Conclusion: For febrile infants at the emergency department, the measurement of lactate is expected to be a useful tool to diagnose serious bacterial infection.
키워드
Infection; Lactic acid; Biomarker
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