패혈증 쇼크에서 바소프레신 투여 시기가 예후에 미치는 영향
Effect of vasopressin on prognosis in sepsis shock
김성은, 이강호, 민문기, 유지호, 이대섭, 이민지, 왕일재,
소속 상세정보
김성은 ( Kim Sung-Eun )
Pusan National University Yangsan Hospital Department of Emergency Medicine
이강호 ( Lee Kang-Ho )
Pusan National University Yangsan Hospital Department of Emergency Medicine
민문기 ( Min Mun-Ki )
Pusan National University Yangsan Hospital Department of Emergency Medicine
유지호 ( Ryu Ji-Ho )
Pusan National University Yangsan Hospital Department of Emergency Medicine
이대섭 ( Lee Dae-Sup )
Pusan National University Yangsan Hospital Department of Emergency Medicine
이민지 ( Lee Min-Jee )
Pusan National University Yangsan Hospital Department of Emergency Medicine
왕일재 ( Wang Il-Jae )
Pusan National University Hospital Department of Emergency Medicine
KMID : 0385920200310020146
Abstract
Objective: This study analyzed the relationship between the timing of vasopressin treatment and the prognosis of patients with septic shock.
Method: Patients who were admitted to a university hospital for one year using vasopressin were studied retrospectively. All records were collected through the medical records; several factors were studied to determine the prognosis of the patient. The 24-hour, 48-hour mortality, and hospital mortality were examined. The difference in the timing of vasopressin administration between death and survival patients was analyzed to determine the effect of the vasopressor on the survival rate using the receiver operating characteristic (ROC) curve.
Results: The general characteristics of the patients in the hospital and survivors were similar. Vasopressin infusion was faster in the surviving patients than in the death patients, but there was no significant difference (survival, 187.0 minutes; interquartile range [IQR], 95.0-548.0 minutes vs. death, 285.5 minutes; IQR, 92.7-739.2). To determine the effect of vasopressor injection on the survival rate, the ROC curve was drawn, and the area under curve was not affected significantly by norepinephrine (NE) 0.416 and vasopressin 0.529. In addition, the duration of the ventilator application was found to increase with increasing NE injection period in survivors (period of application of ventilator: NE injection time, r=0.460, P=0.048; vasopressin, r=0.369, P=0.120).
Conclusion: The prognosis was similar regardless of the timing of vasopressin in patients with septic shock.
키워드
Vasopressin; Septic shock; Norepinephrine; Mortality
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