항-Dia 항체에 의한 신생아 용혈성 질환 1례: 항체선별검사에서 Dia 항원의 포함 고려
A Case of Hemolytic Disease of Newborn due to Anti-Dia: Consideration of the Inclusion of Dia Antigen in Antibody Screening Test
김한솔, 조재구, 김신영, 김경희, 김묘징,
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김한솔 ( Kim Han-Sol )
동아대학교병원 소아청소년과
조재구 ( Jo Chae-Ku )
동아대학교병원 소아청소년과
김신영 ( Kim Sin-Young )
연세대학교 의과대학 진단검사의학교실
김경희 ( Kim Kyeong-Hee )
동아대학교 의과대학 진단검사의학교실
김묘징 ( Kim Myo-Jing )
동아대학교 의과대학 소아과학교실
Abstract
The Diego blood group is expressed as the Dia antigen and Dib antigen, and the frequency of the Dia antigen among the Korean population is estimated to be 9.4~14.5%. We report here on a case of hemolytic disease caused by anti-Dia antibody. A full-term male infant was admitted due to hyperbilirubinemia on the first day of life. The total bilirubin level was decreased after phototherapy, but the hemoglobin level was decreased 6.9 g/dL and an exchange transfusion was then performed. The direct antiglobulin test was strongly positive, but the indirect antiglobulin test using screening blood cells without the Dia antigen was negative. After we suspected neonatal hemolytic disease caused by the anti-Dia antibody, it was confirmed using selected blood cells containing Dia antigen. The newborn and father had DI*A/DI*B and the mother had DI*B. The inclusion of Dia antigens in an unexpected antibody screening test should be actively discussed in Korea.
키워드
Hemolytic disease of newborn; Diego; Hyperbilirubinemia
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