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Transfusion in RhD Mismatch Hematopoietic Stem Cell Transplantation
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±è´ë¿ø ( Kim Dae-Won )
Gachon University College of Medicine Gil Medical Center Department of Laboratory Medicine
±è°æÈñ ( Kim Kyung-Hee )
Gachon University College of Medicine Gil Medical Center Department of Laboratory Medicine
¼ÀÏÇý ( Seo Yiel-Hea )
Gachon University College of Medicine Gil Medical Center Department of Laboratory Medicine
¹ÚÇÊȯ ( Park Pil-Whan )
Gachon University College of Medicine Gil Medical Center Department of Laboratory Medicine
¾ÈÁ¤¿ ( Ahn Jeong-Yeal )
Gachon University College of Medicine Gil Medical Center Department of Laboratory Medicine
¼ÀÚ¿µ ( Seo Ja-Young )
Gachon University College of Medicine Gil Medical Center Department of Laboratory Medicine
Abstract
In some cases, hematopoietic stem cell transplants (HSCT) show differences in the D antigen. In previous studies, there have been few cases of de novo anti-D alloimmunization, and even rarer cases of serious side effects or the outcomes. De novo anti-D alloimmunization has been reported to occur more frequently in minor D mismatch than in major D mismatch. For the RhD type of blood components, RhD-negative type is recommended in transfusion in RhD mismatch HSCT without anti-D in donors and recipients. But in situations of insufficient RhD-negative blood supply, this study suggests that the RhD type of blood components depends on the patients¡¯ RhD type before transplantation, and it depends on the donors¡¯ RhD type after transplantation, and an RhD-positive platelet transfusion may be available.
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Hematopoietic stem cell transplantation; D antigen; Alloimmunization; Mismatch; Transfusion support
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