만삭아와 미숙아에서 혈중 아미노산 농도의 비교
Serum Amino Acid levels in Term and Preterm Neonates
윤유숙, 장미영, 김숙자,
소속 상세정보
윤유숙 ( Youn You-Sook )
충남대학교 의과대학 소아과학교실
장미영 ( Jang Mi-Young )
충남대학교 의과대학 소아과학교실
김숙자 ( Kim Sook-Za )
한국유전학연구소
KMID : 0438520060130010090
Abstract
Purpose:This study was aimed to analyze the level of serum amino acids according to the sex, birth weight, gestational age in neonates.
Methods: Amino acid was measured by tandem mass spectrometry from the dried blood spots. We measured serum alanine, citrulline, glycine, methionine, ornitine, tyrosine, valine, leucine, phenylalanine levels in 172 neonates admitted to the NICU at Chungnam National University hospital from March 2003 to September 2003 and the data was analyzed according to the sex, birth weight, gestational age.
Results: There were no differences of serum amino acid level between term and preterm neonates according to the sex. However, there were significant statistical differences in serum amino acid level according to the birth weight (≥2,500 g vs. <2,500 g) and gestational age (≥37 weeks vs. <37 weeks). The level of alanine, citrulline, glycine, methionine, ornitine, tyrosine, valine, leucine was low in under 2,500 g (P<0.05), and in preterm neonates (P<0.05). Especially, preterm neonates under 1,800 g had low levels of valine and leucine (P<0.05). The serum levels of methionine, ornitine, valine, leucine were low in neonates with gestational age of less than 34 weeks (P<0.05).
Conclusion: Awareness of low serum amino acid levels in preterm neonates is essential to improve nutritional supplements and catch-up growth. (J Korean Soc Neonatol 2006;13:90-96)
키워드
Serum amino acid;Term;Preterm;Neonates
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