조산아에서 제대 동맥 초음파 검사 결과가 주산기 예후에 미치는 영향 -조발형 혈소판 감소증 및 그 위험 인자를 중심으로-
Perinatal Outcome in Preterm Infants with Abnormal Umbilical Artery Doppler Results -Emphasizing on Early Onset Thrombocytopenia and its Risk Factors-
정경은, 김재리, 김병일, 김상덕, 김이경, 최중환, 김도현, 심소연, 김은선, 신승한,
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정경은 ( Joung Kyoung-Eun )
서울대학교 의과대학 소아과학교실
김재리 ( Kim Jae-Lee )
서울대학교 의과대학 소아과학교실
김병일 ( Kim Beyong-Il )
서울대학교 의과대학 소아과학교실
김상덕 ( Kim Sang-Duk )
서울대학교 의과대학 소아과학교실
김이경 ( Kim Ee-Kyung )
서울대학교 의과대학 소아과학교실
최중환 ( Choi Jung-Hwan )
서울대학교 의과대학 소아과학교실
김도현 ( Kim Do-Hyun )
서울대학교 의과대학 소아과학교실
심소연 ( Sim So-Yeon )
서울대학교 의과대학 소아과학교실
김은선 ( Kim Eun-Sun )
서울대학교 의과대학 소아과학교실
신승한 ( Shin Seung-Han )
서울대학교 의과대학 소아과학교실
KMID : 0438520060130020233
Abstract
Purpose: Umbilical artery Doppler study is a commonly used non-invasive tool in high risk pregnancies because of its good correlation with the degree of placental insufficiency. We analyzed hematologic profiles and perinatal outcome of preterm infants with abnormal umbilical artery Doppler results and the risk factors of early onset thrombocytopenia.
Methods: We retrospectively reviewed the medical records of preterm infants under 35 weeks of gestational age at birth who were admitted to the neonatal intensive care unit of Seoul National University Children’s Hospital from January 1, 2002 through December 31, 2004, and whose mothers had undergone umbilical artery Doppler studies within 5 days before delivery. Sixty two neonates were divided into three groups; the 1st group was defined as the patients with normal umbilical artery (UA) systolic/diastolic (S/D) ratio, the 2nd group, with increased UA S/D ratio above 95 percentile, and the 3rd, with absent or reversed end-diastolic flow (AREDF).
Results: Mean nucleated red blood cell (nRBC) counts per 100 white blood cells (WBCs) were 14.2 (0-150), 91.0 (0-262), 301.4 (6-884) (P<0.001), mean WBC counts were 10.8 (0- 34.1), 9.2(3.4-23.9), 5.9(0.5-15.2) (x1,000/mm(3)) (P=0.007), and mean platelet counts were 215.5+/-69.2, 185.9+/-96.7, 100.2+/-50.3 (x1,000/mL)
키워드
Umbilcal artery Doppler;Placental insufficiency;Preterm neonates;Hematolo-gic profile;Nucleated red blood cell;Platelet;Early onset thrombocytopenia
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