Preventive Effect of Korean Red Ginseng on Cancers in AIDS Patients
조영걸, 이희정, 허숙진, 남정현, 오원일, Maeng Sung-Ho, 신영오, 원영호, 김능수, 조군제, 남기열,
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조영걸 ( Cho Young-Keol )
울산대학교 의과대학 미생물학교실
이희정 ( Lee Hee-Jung )
울산대학교 의과대학 미생물학교실
허숙진 ( Hur Sook-Jin )
국립보건원 Center for AIDS Research
남정현 ( Nam Jung-Hyun )
울산대학교 의과대학 미생물학교실
오원일 ( Oh Won-Il )
울산대학교 의과대학 임상병리학과
( Maeng Sung-Ho )
국립보건원 Center for AIDS Research
신영오 ( Shin Yung-Oh )
강원대학교 의과대학 미생물학교실
원영호 ( Won Young-Ho )
전남대학교 의과대학 피부과학교실
김능수 ( Kim Nung-Soo )
경북대학교 의과대학 내과학교실
조군제 ( Cho Goon-Jae )
부산대학교 의과대학 내과학교실
남기열 ( Nam Ki-Yeul )
한국인삼연초연구원 인삼효능연구부
KMID : 0603519970020010045
Abstract
We have treated 130 human immunodeficiency virus-1 (HIV-1) infected individuals with Korean red ginseng (RG) since late 1991. CD4+T cell and CD8+T cell counts using flow cytometry have been routinely measured nearly every to 3∼6 months. Other immunnological markers have been measured for them. This study was attempted to evaluate whether Korean red ginseng (RG) intake has positive effects on survival and the prevention of cancer in HIV-1 inflected individuals. Among total number of patients who were diagnosed with HIV-1 antibody positive by Dec. 31, 1992, 64 cases expired by Dec. 31, 1996. The patients were divided into two groups, those with the intake of RG (n=21) and those without it (n=43), and the incidence of cancer was compared between the two groups. Data on cancer were collected via medical records. The duration of RG intake in 21 patients was 13.4±10.6 months (range. 3∼44; median, 11.5). The causes of death were AIDS (n=48), suicide (n=10), diseases other than AIDS (n=4), and accident (n=2). Cancers were confirmed in 8 (16.6%) of 48 who were expired by AIDS. Excluded 16 cases of death caused by diseases other than AIDS, the cancer incidence between two groups with RG intake and without it showed significant difference; 5.0% (1/20) versus 25.0% (7/28), respectively (Relative risk, 0.20; P<0.01). These results, as nationwide data, suggest that long-term intake of RG may have a preventive effect on cancers in AIDS patients.
키워드
Cancer; AIDS; Korean red ginseng; CD4; T cell
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