김치에서 분리한 유산균의 항돌연변이 효과
Antimutagenic Activities of Lactic Acid Bacteria Isolated from Kimchi
손태진, 김소희, 박건영,
소속 상세정보
손태진 ( Son Tae-Jin )
부산대학교 김치연구소
김소희 ( Kim So-Hee )
동주대학교 환경보건연구소
박건영 ( Park Kun-Young )
부산대학교 김치연구소
KMID : 0603519980030010065
Abstract
The antimutagenic acitivities of cell body of several lactic acid bacteria (LAB) isolated from kimchi were studied using the methods of Ames mutagenicity test and SOS chromotest. The mutagenicities mediated by 4-nitroquinoline-1-oxide (4-NQO), 2-amino-3,4-dimethyl-imidazo (4,5-f) quinoline (MeIQ), and 3-amino-1-methyl-5H-pyrido [4,3-b] indole (Trp-P2) were effectively supressed by LAB in both tests. However, the mutagenicity of N-methyl-N’-nitro-N-nitrosoguanidine (MNNG) w as not markedly inhibited by LAB preparation. Cell body of Leuconostoc mesenteroides exhibited higher antimuatagenic activity on 4-NQO, MeIQ, MNNG than LABs from other lactic acid bacteria. Pediococcus acidilactici was not effective on direct mutagens (4-NQO, MNNG), but the antimatagenic effect on MeIQ and Trp-P2 were similar to those of other LAB preparations. In this study, LAB from kimchi (Leuconostoc mesenteroides, Lactobacillus brevis, Lactobacillus fermentum, Lactobacillus plantarum, Pediococcos acidilactici) revealed high capability of prevention of the mutation induced by 4-NQO, MeIQ and Trp-P2 as much as (or higher than) Lactobacillus acidophillus from yogurt, regardless of their viability. These results suggested that lactic acid bacteria in kimchi might have the cancer preventive function.
키워드
Lactic acid bacteria; Kimchi; Antimutagenicity; 4-NQO; MNNG; MeIQ; Trp-P2
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