된장에서 분리한 리놀레산의 In vitro항돌연변이 및 항발암효과
In vitro Antimutagenic and Anticarcinogenic Effect of Linoleic Acid Identified from Doenjang
이정민, 문숙희, 박건영,
소속 상세정보
이정민 ( Lee Jeong-Min )
부산대학교 식품영양학과
문숙희 ( Moon Suk-Hee )
경남정보대학 식품과학계열
박건영 ( Park Kun-Young )
부산대학교 식품영양학과
KMID : 0603519980030010074
Abstract
Antimutagenic and anticarcinogenic effects of linoleic acid were studied by using spore rec assay and SOS chromotest, and C3H/10T1/2 cells, respectively. Strong antimutagenic activities toward N-methyl-N’-nitro-N-nitrosoguanidine (MNNG) and 4-nitroquino-line-1-oxide (4-NQO) were observed when linoleic acid, one of active compounds identified from traditional doenjang, was added in the test systems. In spore rec assay using Bacillus subtills Hl7 (rec+) and M45 (rec-), linoleic acid considerably inhibited the mutagenesis induced by MNNG. In SOS chromotest using Escherichia coli PQ37, linoleic acid also exhibited strong antimutagenic activity toward 4-NQO. Linoleic acid decreased the cytotoxicity induced by carcinogen, MNNG in C3H/10T1/2 cells. Type Ⅲ foci formation rate from the aflatoxin Bl (AFBl) treatment also decreased when linoleic acid was added to the C3H/10T1/2 cells, suggesting that linoleic acid might prevent the carcinogenesis mediated by AFBl.
키워드
Linoleic acid; Antimutagenicity; Anticarcinogenicity; C3H/10T1/2 cells
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